AI Article Synopsis
- HLTF, a member of the SWI/SNF protein family, is found to be highly expressed in hepatocellular carcinoma (HCC) tissues compared to non-tumor tissues.
- Increased levels of HLTF correlate with poorer patient outcomes in HCC.
- Experimental knockdown of HLTF reduces the growth, migration, and invasion of HCC cells, indicating that HLTF may serve as a potential therapeutic target for HCC treatment.
Article Abstract
Helicase-like transcription factor (HLTF) belongs to the family of SWI/SNF proteins, which has been reported to exert oncogenic function in several human cancers. However, to date, its functional role in hepatocellular carcinoma (HCC) has not been revealed. Here, we found that HLTF was highly expressed in HCC tissues compared to nontumor tissues. Additionally, upregulation of HLTF was significantly associated with poor prognosis of patients with HCC. Functional experiments demonstrated that knockdown of HLTF expression significantly inhibited the proliferation, migration, and invasion of HCC cells in vitro, and suppressed tumor growth in vivo. In conclusion, our results suggest that upregulation of HLTF is associated with the development of HCC, and HLTF may be a potential therapeutic target for HCC treatment.
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| http://dx.doi.org/10.1007/s13577-023-00917-3 | DOI Listing |
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