Riding up the escaLEC-TOR for valvular health.

J Cell Biol

Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Published: June 2023

Endothelial-lined valves assure unidirectional flow in the lymphatic system. In this issue, Saygili Demir et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202207049) demonstrate how continuous repair of these valves occur, beginning with mTOR-activated cell replication in valve sinuses, and followed by cell migration to cover the valve surface.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225616PMC
http://dx.doi.org/10.1083/jcb.202305005DOI Listing

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