Gallbladder polyps are a common incidental finding. Although most of these are benign, differentiating non-neoplastic from neoplastic polyps is challenging. Trans-abdominal ultrasound is the primary imaging study for diagnosing and monitoring gallbladder polyps. In challenging cases, the use of endoscopic ultrasound or contrast-enhanced endoscopic ultrasound could assist in making decisions. According to current guidelines, a cholecystectomy is recommended in patients with polyps measuring 10 mm or larger and in symptomatic patients with polyps measuring less than 10 mm. A cholecystectomy is also recommended if one or more risk factors for malignancy are present in patients with polyps measuring 6-9 mm. These risk factors include age older than 60 years, primary sclerosing cholangitis, Asian ethnicity, and sessile polyps, including focal gallbladder wall thickening >4 mm. Follow-up ultrasound is recommended at six months, one year, and two years for polyps measuring 6-9 mm in patients without risk factors for malignancy, and for polyps less than 5 mm in patients with one or more risk factors for malignancy. Discontinuing the surveillance could be considered in the absence of growth. Follow-up is not required for polyps measuring less than 5 mm in patients without the risk factors for a malignancy. On the other hand, the evidence for the guidelines is still lacking and of low quality. The management of gallbladder polyps should be individualized based on the currently available guidelines.
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http://dx.doi.org/10.4166/kjg.2023.038 | DOI Listing |
Am J Gastroenterol
March 2025
Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA.
Gastric premalignant conditions (GPMC) are common and include atrophic gastritis, gastric intestinal metaplasia, dysplasia, and certain gastric epithelial polyps. GPMC have an increased risk of progression to gastric adenocarcinoma. Gastric cancer (GC) in the United States represents an important cancer disparity because incidence rates are 2- to 13-fold greater in non-White individuals, particularly early-generation immigrants from regions of high GC incidence.
View Article and Find Full Text PDFBMC Public Health
March 2025
Faculty of Medicine, Damascus University, Damascus, Syria.
Background: Colorectal cancer (CRC) is the third most common cancer globally, with rising incidence in developing countries due to lifestyle and dietary shifts. CRC often presents with late-stage symptoms, leading to higher mortality. Early detection through screening can significantly improve survival rates.
View Article and Find Full Text PDFCancer Epidemiol Biomarkers Prev
March 2025
University of South Carolina, Columbia, SC, United States.
Background: Black Americans experience higher colorectal cancer (CRC) incidence than Whites, despite undergoing prevention screenings similar to Whites since 2010. We compared Black and White patients' colorectal adenoma status at screening colonoscopy, a measure of CRC risk.
Methods: Using cross-sectional, observational data, we studied colorectal adenomas at first-time screening colonoscopy of average risk patients aged 40-89 years, screened between September 2001 and July 2016 in South Carolina.
BMC Womens Health
March 2025
Department of Obstetrics and Gynecology, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyi Road, Yangfangdian Street, Haidian District, Beijing, China.
Purpose: This study aimed to explore the relationship between endometrial thickness and lesions in asymptomatic postmenopausal women and identify diagnostic thresholds for lesions.
Methods: A total of 279 postmenopausal asymptomatic women aged 40 years or older with endometrial thickness ≥ 4 mm were retrospectively selected in our hospital, from January 2018 to June 2023, there were 33 cases's operations which were failed due to the cervical stenosis, 8cases who used hormone replacement therapy within the past year, 7 cases with hysteromyoma that affect the shape of the uterine cavity line, and 5cases's hysteroscopic tissue acquisition were failed. Finally, A retrospective study was conducted on the endometrial thickness of 226 postmenopausal asymptomatic women measured by transvaginal ultrasound and those with thickening were subjected to hysteroscopy and pathological examination of endometrial biopsy tissues, and were divided into a normal group (80 cases), benign lesion group (143 cases), and malignant lesion group (3 cases) according to the pathology results.
J Allergy Clin Immunol
March 2025
Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:
Background: Thymic stromal lymphopoietin (TSLP) and its functional cleavage products are elevated in nasal polyps (NPs) and play important roles in type 2 (T2) inflammation in chronic rhinosinusitis (CRS) with NPs (CRSwNP) by activating myeloid dendritic cells (mDCs) and group 2 innate lymphoid cells (ILC2s). However, whether tezepelumab, a human monoclonal antibody against TSLP, inhibits functional cleaved TSLP and the role of TSLP in CRS without NPs (CRSsNP) have not been studied.
Objective: To investigate the effects of tezepelumab on cleaved TSLP in CRS.
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