This article summarises our review of 41 Corynebacterium diphtheriae wound swab isolates from the tropical Northern Territory of Australia. On polymerase chain reaction and whole genome sequencing, no isolates were toxigenic strains.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.33321/cdi.2023.47.31 | DOI Listing |
Arch Dis Child
January 2025
Department of Infection and Immunity, Monash Children's Hospital, Clayton, Victoria, Australia.
We conducted patient chart reviews and whole-genome sequencing of wound specimens containing presumptive Corynebacterium ulcerans from Vancouver, British Columbia, Canada, during July 2019-July 2023. Sequencing confirmed 8/14 isolates were C. ramonii and identified 2 distinct clusters.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095.
To successfully mount infections, nearly all bacterial pathogens must acquire iron, a key metal cofactor that primarily resides within human hemoglobin. causes the life-threatening respiratory disease diphtheria and captures hemoglobin for iron scavenging using the surface-displayed receptor HbpA. Here, we show using X-ray crystallography, NMR, and in situ binding measurements that selectively captures iron-loaded hemoglobin by partially ensconcing the heme molecules of its α subunits.
View Article and Find Full Text PDFWe report a cluster of infections with genetically related toxigenic Corynebacterium diphtheriae linked to an outbreak among asylum seekers in Switzerland that subsequently affected patients without known exposure. This discovery highlights the importance of rapid, interdisciplinary outbreak investigations and regular vaccination status assessment, especially in elderly populations with waning immunity.
View Article and Find Full Text PDFAn Acad Bras Cienc
December 2024
Universidade CEUMA, Laboratório de Cências Biomédicas, Rua Josué Montello, 1, Renascença II, 65075-120 São Luís, MA, Brazil.
The objective of this study was to investigate the chemical composition of Syzygium aromaticum essential oil (SAEO), both as its toxicity and biological activities on Corynebacterium diphtheriae. The essential oil (EO) was obtained by hydrodistillation and verified by GC-MS. The main chemical components were eugenol (48.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!