A multifunctionally reversible detector: Photoacoustic and dual-channel fluorescence sensing for SO/HO.

Anal Chim Acta

School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Anhui University, Hefei, 230601, PR China; Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University) Ministry of Education, Hefei, 230601, PR China; Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Hefei, 230601, PR China; Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Hefei, 230601, PR China. Electronic address:

Published: July 2023

In this work, the phenothiazine fragment with powerful electron-donating ability was specifically selected to construct a multifunctional detector (noted as T1) in double-organelle with near-infrared region I (NIR-I) absorption. The changes of SO/HO content in mitochondria and lipid droplets were observed through red/green channels respectively, which was due to the reaction between benzopyrylium fragment of T1 and SO/HO to achieve red/green fluorescence conversion. Additionally, T1 was endowed with photoacoustic properties deriving from NIR-I absorption to reversibly monitor SO/HOin vivo. This work was significant for more accurately deciphering the physiological and pathological processes in living organisms.

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http://dx.doi.org/10.1016/j.aca.2023.341181DOI Listing

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