Background: Systemic sclerosis is an autoimmune disease characterised by endothelial dysfunction and fibrosis of the skin and internal organs. Cardiac involvement during systemic sclerosis can be primary or secondary to pulmonary arterial hypertension and renal pathology. Among the disorders in systemic sclerosis, prolongation of QTc time is also associated with more anti-RNA polymerase III antibodies, longer duration, and severity of disease.
Methods: This case-control study was performed on 35 patients with systemic scleroderma who filled in the American Society of Rheumatism (ACR / EULAR criteria) and 35 healthy subjects prior to entering the study. Then, the QTc distance was extracted from the electrocardiogram and calculated using the formula. The measured QTc distance in the electrocardiogram, QTc> 440ms in men and QTc> 460ms in women, was defined as QTc long. The patients and the control group then underwent echocardiography, and changes in QTc interval and their relations with echocardiographic findings were evaluated.
Results: The results of this study indicated a significant relationship between QTc distance in patients with scleroderma compared with healthy controls. There was also a significant relationship between QTc and Skin Score of patients. However, there was no significant correlation between QTc distance and age, duration of disease, Anti-Centromere, Anti-Scl70, and pulmonary artery pressure.
Conclusion: This study concludes that patients with scleroderma are at high risk for cardiac conduction impairment. The only factor that significantly correlated with QTc was the Skin Score of the patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201100 | PMC |
| http://dx.doi.org/10.31138/mjr.34.1.61 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ferric carboxymaltose reduces the burden of arrhythmic events in heart failure with reduced ejection fraction: the role of the non-invasive arrhythmic biomarkers.
Hellenic J Cardiol
November 2024
Third Cardiology Department, School of Medicine, Aristotle University of Thessaloniki, Hippokrateion General Hospital, Thessaloniki, Greece. Electronic address:
Objective: Treating iron deficiency (ID) with ferric carboxymaltose (FCM) in patients with heart failure with reduced ejection fraction (HFrEF) enhances morbidity, quality of life (QoL), and exercise capacity.
Methods: In the presented single-center, prospective follow-up study, symptomatic patients with HFrEF with ID and CIEDs scheduled for IV FCM were followed up for 12-months. Arrhythmic activity was evaluated from CIEDs and non-invasive markers from Holter recordings before and after FCM.
Electrocardiographic Changes, Mortality, and Late Period Findings in Methyl Alcohol Poisoning.
J Clin Med
October 2024
Department of Emergency Medicine, Faculty of Medicine, Gaziantep University, Gaziantep 27310, Turkey.
Article Synopsis
- - Methyl alcohol poisoning (MAP) can cause serious health issues and high mortality rates, prompting a study to analyze its effects on electrocardiography (ECG) and long-term complications over a six-year period.
- - The retrospective study involved 227 patients, with a mean age of 43.23 years; findings included significant QTc intervals and various ECG abnormalities, with a mortality rate of 21.6% linked to severe acidosis.
- - Key results showed that patients who died had a notably lower pH and higher QTc distance, indicating severe metabolic disturbances; the study identified new ECG conditions in patients with MAP.
Electrocardiographic ventricular arrhythmia parameters during diagnosis and after the treatment of acromegaly: A case-control study.
Heliyon
October 2024
Etlik City Hospital, Department of Endocrinology and Metabolism, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, Ankara, Turkey.
Article Synopsis
- - The study investigates the ECG characteristics of 103 acromegaly patients to assess the risk of cardiovascular complications and life expectancy, highlighting the significance of the Tp-e interval and its ratios as indicators of ventricular arrhythmia risk.
- - Results show that patients with both baseline and current ECGs experienced a decrease in heart rate, QRS duration, and several arrhythmia parameters, which were similarly affected regardless of whether the patients were in active or remission stages of the disease.
- - The conclusion emphasizes that treatment leads to improved ventricular arrhythmia parameters in acromegaly patients, which correlates with a significant reduction in IGF-1 levels, even in those with ongoing active disease.
QTc is Prolonged in Patients with SSc and Associates with Skin Score.
Mediterr J Rheumatol
March 2023
Golestan Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Background: Systemic sclerosis is an autoimmune disease characterised by endothelial dysfunction and fibrosis of the skin and internal organs. Cardiac involvement during systemic sclerosis can be primary or secondary to pulmonary arterial hypertension and renal pathology. Among the disorders in systemic sclerosis, prolongation of QTc time is also associated with more anti-RNA polymerase III antibodies, longer duration, and severity of disease.
View Article and Find Full Text PDFEffects of Fentanyl Versus Remifentanil Pretreatment on the QTc Interval in Patients Undergoing Rapid Sequence Intubation: A Randomized Clinical Trial.
Anesth Pain Med
October 2022
Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Background: One of the complications of laryngoscopy is cardiac dysrhythmia due to an increased QT interval.
Objectives: This study aimed to compare the effect of fentanyl and remifentanil on QTc interval in patients undergoing intubation by the rapid method in 2020.
Methods: In this study, 50 patients without a history of heart disease and without a history of drug use who were candidates for rapid intubation in the emergency department were selected and divided into two groups.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!