There are few reports of dupilumab-induced psoriasis recently published. Here, we present a case of a 50-year-old female with a three-month history of persistent itchy scalp lesions. She had an unremarkable past medical history except that she was diagnosed with prurigo nodularis (PN) three years ago and was on dupilumab treatment for one year. Skin examination revealed multiple silvery scaly plaques on her scalp. The examination of the nails and mucous membranes was normal; there were no skin lesions. Based on the above clinical findings, the patient was diagnosed with dupilumab-induced scalp psoriasis. Dupilumab was stopped. Anti-psoriasis treatment (0.05% betamethasone dipropionate-calcepitriol gel) was started and the patient showed improvement. She was put under periodic follow-up.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202743PMC
http://dx.doi.org/10.7759/cureus.37992DOI Listing

Publication Analysis

Top Keywords

dupilumab-induced scalp
8
scalp psoriasis
8
prurigo nodularis
8
psoriasis patient
4
patient prurigo
4
nodularis case
4
case report
4
report reports
4
reports dupilumab-induced
4
dupilumab-induced psoriasis
4

Similar Publications

Atopic dermatitis and psoriasis are traditionally considered diseases that cannot coexist, since they are described as the result of the activation of opposing inflammatory pathways. However, this belief has been debunked, and numerous cases of psoriasis induced by dupilumab, a biologic treatment for atopic dermatitis, have been reported. We report three cases of dupilumab-induced psoriasis and we present a literature review including cases of "de novo" psoriasis and of the relapse of psoriasis that occurred during treatment with dupilumab.

View Article and Find Full Text PDF

There are few reports of dupilumab-induced psoriasis recently published. Here, we present a case of a 50-year-old female with a three-month history of persistent itchy scalp lesions. She had an unremarkable past medical history except that she was diagnosed with prurigo nodularis (PN) three years ago and was on dupilumab treatment for one year.

View Article and Find Full Text PDF
Article Synopsis
  • * A case is presented of a patient who developed oral and skin lichen planus after taking dupilumab for severe atopic dermatitis, with symptoms appearing after 11 months of treatment.
  • * The treatment for the patient's lichen planus included stopping dupilumab and using oral corticosteroids and UVB phototherapy, which resulted in significant improvement of the condition.
View Article and Find Full Text PDF
Article Synopsis
  • This report explores the occurrence of psoriasiform eruptions in children treated with dupilumab for atopic dermatitis, highlighting a previously noted risk in adults.
  • A review of cases showed that six children, aged 4-18, developed new psoriasiform dermatitis after an average of 8 months on dupilumab, primarily affecting common psoriasis locations.
  • Most patients responded well to topical corticosteroids while continuing dupilumab, although one child experienced unmasked psoriasis due to inadequate response to the treatment.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!