AI Article Synopsis
- Coagulase negative staphylococci, while typically not linked to severe diseases, can occasionally lead to life-threatening infections.
- A clinical case is presented where a patient developed bacteremia due to a strain resistant to both methicillin and linezolid, after prior treatment with linezolid.
- Whole genome sequencing revealed a common mutation and several resistance genes, indicating that minor staphylococci can adapt and complicate treatment options.
Article Abstract
Although coagulase negative staphylococci are rarely associated with complicated diseases, in some cases they cause life-threatening infections. Here we described a clinical case of a bacteremia due to a methicillin- and linezolid-resistant in a patient previously treated with linezolid. Whole genome sequencing revealed the common mutation G2576T in all rDNA 23S alleles and several acquired resistance genes. Moreover, the isolate was epidemiologically distant from the NRCS-A clade, usually responsible for nosocomial infections in neonatal intensive care units. Our findings further confirm the ability of minor staphylococci to acquire antibiotic resistances and challenge the treatment of these infections.
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| http://dx.doi.org/10.1089/mdr.2022.0330 | DOI Listing |
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