When using a sparse array, locating the target signal of a high-frequency component is difficult. Although forecasting the direction in a sparse situation is challenging, the frequency-wavenumber (f-k) spectrum can simultaneously determine the direction and frequency of the analyzed signal. The striation of the f-k spectrum shifts along the wavenumber axis in a sparse situation, which reduces the spatial resolution required to determine the target's direction using the f-k spectrum. In this study, f-k spectra of a high-frequency signal were used for near-field source localization. Snapping shrimp sounds (5-24 kHz) from SAVEX15 (a shallow-water acoustic variability experiment conducted in May 2015) were used as the data source, and a simulation was used to evaluate the proposed method. Beam steering was performed before creating the f-k spectrum to improve spatial resolution. We found that the spatial resolution was improved, and the location of the sound source could be determined when a signal with beam steering was utilized. The shrimp sound from SAVEX15, a near-field broadband signal, was used to determine the shrimp's location (range, 38 m; depth, 100 m) and the tilt of the vertical line array. These results suggest that the proposed analysis helps to accurately estimate the location of sound source.
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http://dx.doi.org/10.1121/10.0019552 | DOI Listing |
Neurobiol Dis
January 2025
The University of Texas Southwestern Medical Center, Department of Neurology, Dallas, TX, United States of America; The University of Texas Southwestern Medical Center, Department of Psychiatry, Dallas, TX, United States of America; The University of Texas Southwestern Medical Center, Department of Pediatrics, Dallas, TX, United States of America; The University of Texas Southwestern Medical Center, Department of Neuroscience, Dallas, TX, United States of America. Electronic address:
Loss of function in the subunits of the GTPase-activating protein (GAP) activity toward Rags-1 (GATOR1) complex, an amino-acid sensitive negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), is implicated in both genetic familial epilepsies and NDDs (Baldassari et al., 2018). Previous studies have found seizure phenotypes and increased activity resulting from conditional deletion of GATOR1 function from forebrain excitatory neurons (Yuskaitis et al.
View Article and Find Full Text PDFNeurol Genet
December 2024
From the Department of Neurology (S.A.B., A.J.A., G.F.K., N.K., W.O.T.); Division of Hematology (J.P.A., J.C.V., R.G.); Division of Hematopathology (K.R.); Division of Neuroradiology (P.M.); Department of Clinical Genomics (Q.K.G.T., L.N.V.); Division of General Internal Medicine (K.L.S.); Department of Dermatology (S.S.D., H.S.M.); Division of Endocrinology (C.J.D.-P.), Diabetes, Nutrition; and Center for Multiple Sclerosis and Autoimmune Neurology at Mayo Clinic (W.O.T.), Rochester, MN.
Objectives: Pathogenic variants are known to cause autosomal recessive disease with a spectrum of systemic involvement. We sought to expand on the spectrum of variants and describe potential treatment.
Methods: We describe a case of newly diagnosed -related disorder, also known as H syndrome or familial histiocytosis, associated with CNS inflammatory pseudotumor and spinal cord compression.
Circulation
October 2024
Cardiovascular Imaging Program, Departments of Medicine and Radiology (X.X., S. Divakaran, B.N.W., J.H., S.S.L., B.A., M.F.K., R.B., S. Dorbala, J.M.B., M.F.D.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Background: Coronary microvascular dysfunction has been implicated in the development of hypertensive heart disease and heart failure, with subendocardial ischemia identified as a driver of sustained myocardial injury and fibrosis. We aimed to evaluate the relationships of subendocardial perfusion with cardiac injury, structure, and a composite of major adverse cardiac and cerebrovascular events consisting of death, heart failure hospitalization, myocardial infarction, and stroke.
Methods: Layer-specific blood flow and myocardial flow reserve (MFR; stress/rest myocardial blood flow) were assessed by N-ammonia perfusion positron emission tomography in consecutive patients with hypertension without flow-limiting coronary artery disease (summed stress score <3) imaged at Brigham and Women's Hospital (Boston, MA) from 2015 to 2021.
Invest Ophthalmol Vis Sci
May 2024
Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, Western Australia, Australia.
Purpose: To describe the clinical, electrophysiological and genetic spectrum of inherited retinal diseases associated with variants in the PRPH2 gene.
Methods: A total of 241 patients from 168 families across 15 sites in 9 countries with pathogenic or likely pathogenic variants in PRPH2 were included. Records were reviewed for age at symptom onset, visual acuity, full-field ERG, fundus colour photography, fundus autofluorescence (FAF), and SD-OCT.
J Child Adolesc Psychopharmacol
August 2024
R.F.K. Children's Evaluation and Rehabilitation Center, Children's Hospital at Montefiore, The University Hospital for Albert Einstein College of Medicine, Bronx, New York, USA.
Despite policy emphasis on early identification, many children with Autism are diagnosed late, with some being diagnosed as late as adolescence. The objective of this study was to examine the demographics and clinical characteristics of school-age children and adolescents initially diagnosed with Autism age 7 and older, in an urban, university-affiliated multidisciplinary center that evaluates/treats youth with developmental disabilities. A chart review of all school-age children and adolescents referred for evaluation to determine if the child has developmental disabilities from January 2019 to May 2023 was performed.
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