The frequency of major , and variants in Asian, Native Hawaiian and Pacific Islander women subgroups: implications for personalized statins dosing.

The frequencies of and and in specific Asian, Native Hawaiian and Pacific Islander (NHPI) subgroups are unknown. Repository DNA samples from 1064 women self-identifying as Filipino, Korean, Japanese, Native Hawaiian, Marshallese or Samoan and aged 18 years or older were used for targeted sequencing of three genetic variants (rs4149056, rs1799853 and rs1057910). was significantly less frequent in NHPI women (0.5-6%) than in Europeans (16%). Except for Koreans, (0-1.4%) and (0.5-3%) were significantly less frequent in all subgroups than in Europeans (8 and 12.7%, respectively). Prior reports showed that Asian and NHPI individuals have significantly higher Q141K allele frequency (13-46%) than Europeans (9.4%). Combined phenotype rates for rosuvastatin and fluvastatin revealed that Filipinos and Koreans had the highest frequencies of statin-associated myopathy symptoms risk alleles. Differences in , and allele frequencies among different racial and ethnic subgroups highlight the need for increased diversity in pharmacogenetic research. Risk alleles for statin-associated myopathy symptoms are more prevalent in Filipinos, underscoring the importance of genotype-based statin dosing.