AI Article Synopsis
- The study analyzed T-cell receptor gamma (TRG) recombination reads from melanoma tumor exome files to evaluate their relationship with cancer testis antigens like FAM133A and CRISP2.
- The research found that certain TRG CDR3 amino acid sequences showed better chemical compatibility with these antigens, positively correlating with improved survival rates for patients in both tumor datasets.
- These findings suggest potential methods for stratifying melanoma patients and highlight the possibility of discovering new, effective targets for melanoma treatment.
Article Abstract
We assessed the T-cell receptor gamma (TRG) recombination reads from the cancer genome atlas melanoma tumor exome files and the TRG recombination reads from an independent, melanoma exome file dataset, from the Moffitt Cancer Center. TRG complementarity determining region-3 (CDR3) amino acid (AA) sequences were assessed for chemical complementarity to cancer testis antigens, with such complementarity for FAM133A and CRISP2 associated with better survival probabilities for both datasets. These results, along with related TRG CDR3 AA chemical feature assessments provided in this report, have indicated opportunities for melanoma patient stratifications based on the recovery of TRG recombination reads from both tumor and blood samples, and the results may point towards novel, effective melanoma antigens.
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| http://dx.doi.org/10.1097/CMR.0000000000000899 | DOI Listing |
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