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* Lysosomal membrane proteins (LMPs) are essential for lysosomal functions, playing key roles in various stages of autophagy, such as vesicle formation and fusion with lysosomes.
* Dysfunctions in LMP-mediated autophagy are linked to serious conditions like neurodegenerative diseases and cancer, highlighting the importance of these proteins in health and disease.
Article Abstract
As a self-degrading and highly conserved survival mechanism, autophagy plays an important role in maintaining cell survival and recycling. The discovery of autophagy-related (ATG) genes has revolutionized our understanding of autophagy. Lysosomal membrane proteins (LMPs) are important executors of lysosomal function, and increasing evidence has demonstrated their role in the induction and regulation of autophagy. In addition, the functional dysregulation of the process mediated by LMPs at all stages of autophagy is closely related to neurodegenerative diseases and cancer. Here, we review the role of LMPs in autophagy, focusing on their roles in vesicle nucleation, vesicle elongation and completion, the fusion of autophagosomes and lysosomes, and degradation, as well as their broad association with related diseases.
