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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207701 | PMC |
| http://dx.doi.org/10.1186/s13064-023-00172-0 | DOI Listing |
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Proteome-wide Mendelian randomization provides novel insights into the pathogenesis and druggable targets of osteoporosis.
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October 2024
Department of Orthopedics, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Background: With the aging population, the prevalence and impact of osteoporosis are expected to rise, and existing anti-osteoporosis agents have limitations due to adverse events. This study aims to discover novel drug targets for osteoporosis.
Methods: The protein data were obtained from the latest proteome-wide association studies (PWAS) including 54, 219 participants.
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Correction: Lrig1 expression identifies quiescent stem cells in the ventricular‑subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation.
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Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, 84112‑5331, USA.
Correction: Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life.
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Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, 84112‑5331, USA.
Author Correction: Lrig1-expressing epidermal progenitors require SCD1 to maintain the dermal papilla niche.
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Institute of Medical Biology (IMB)/Skin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research (A*STAR), 11 Mandalay Road, Clinical Sciences Building #17‑01, Singapore, 308232, Republic of Singapore.
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