AI Article Synopsis
- Little research exists on how left ventricular ejection fraction (EF) affects ischemic outcomes in patients with acute decompensated heart failure (ADHF).
- A study analyzing data from 2001 to 2021 identified that 17.3% of ADHF patients had heart failure with mid-range EF (HFmrEF), which was associated with higher rates of comorbidities like diabetes and ischemic heart disease.
- The findings show that patients with HFmrEF experienced a higher rate of acute myocardial infarction (AMI) compared to those with preserved EF (HFpEF) and reduced EF (HFrEF), indicating a need for further research on the relationship between HFmrEF and ischemic outcomes.
Article Abstract
Background: Little research has been done on ischemic outcomes related to left ventricular ejection fraction (EF) in acute decompensated heart failure (ADHF).
Methods: A retrospective cohort study was conducted between 2001 and 2021 using the Chang Gung Research Database. ADHF Patients discharged from hospitals between January 1, 2005, and December 31, 2019. Cardiovascular (CV) mortality and heart failure (HF) rehospitalization are the primary outcome components, along with all-cause mortality, acute myocardial infarction (AMI) and stroke.
Results: A total of 12,852 ADHF patients were identified, of whom 2,222 (17.3%) had HFmrEF, the mean (SD) age was 68.5 (14.6) years, and 1,327 (59.7%) were males. In comparison with HFrEF and HFpEF patients, HFmrEF patients had a significant phenotype comorbid with diabetes, dyslipidemia, and ischemic heart disease. Patients with HFmrEF were more likely to experience renal failure, dialysis, and replacement. Both HFmrEF and HFrEF had similar rates of cardioversion and coronary interventions. There was an intermediate clinical outcome between HFpEF and HFrEF, but HFmrEF had the highest rate of AMI (HFpEF, 9.3%; HFmrEF, 13.6%; HFrEF, 9.9%). The AMI rates in HFmrEF were higher than those in HFpEF (AHR, 1.15; 95% Confidence Interval, 0.99 to 1.32) but not in HFrEF (AHR, 0.99; 95% Confidence Interval, 0.87 to 1.13).
Conclusion: Acute decompression in patients with HFmrEF increases the risk of myocardial infarction. The relationship between HFmrEF and ischemic cardiomyopathy, as well as optimal anti-ischemic treatment, requires further research on a large scale.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207615 | PMC |
| http://dx.doi.org/10.1186/s12872-023-03286-9 | DOI Listing |
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