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Stings of certain ant species (Hymenoptera: Formicidae) can cause intense, long-lasting nociception. Here we show that the major contributors to these symptoms are venom peptides that modulate the activity of voltage-gated sodium (Na) channels, reducing their voltage threshold for activation and inhibiting channel inactivation. These peptide toxins are likely vertebrate-selective, consistent with a primarily defensive function. They emerged early in the Formicidae lineage and may have been a pivotal factor in the expansion of ants.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206162 | PMC |
| http://dx.doi.org/10.1038/s41467-023-38839-1 | DOI Listing |
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