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ChagasDB: 80 years of publicly available data on the molecular host response to Trypanosoma cruzi infection in a single database. | LitMetric

ChagasDB: 80 years of publicly available data on the molecular host response to Trypanosoma cruzi infection in a single database.

Database (Oxford)

Institut National de la Santé Et de la Recherche Médicale (INSERM), Unité Mixte de Recherche (UMR)_1090, Aix Marseille Université, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa, Marseille 13288, France.

Published: May 2023

AI Article Synopsis

Article Abstract

Chagas disease is a parasitical disease caused by Trypanosoma cruzi which affects ∼7 million people worldwide. Per year, ∼10 000 people die from this pathology. Indeed, ∼30% of humans develop severe chronic forms, including cardiac, digestive or neurological disorders, for which there is still no treatment. In order to facilitate research on Chagas disease, a manual curation of all papers corresponding to 'Chagas disease' referenced on PubMed has been performed. All deregulated molecules in hosts (all mammals, humans, mice or others) following T. cruzi infection were retrieved and included in a database, named ChagasDB. A website has been developed to make this database accessible to all. In this article, we detail the construction of this database, its contents and how to use it. Database URL https://chagasdb.tagc.univ-amu.fr.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205463PMC
http://dx.doi.org/10.1093/database/baad037DOI Listing

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