BMJ Open
Department of Pediatrics, The University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.
Published: May 2023
Objective: The Bayley Scales of Infant Development (BSID) is the most used diagnostic tool to identify neurodevelopmental disorders in children under age 3 but is challenging to use in low-resource countries. The Ages and Stages Questionnaire (ASQ) is an easy-to-use, low-cost clinical tool completed by parents/caregivers that screens children for developmental delay. The objective was to determine the performance of ASQ as a screening tool for neurodevelopmental impairment when compared with BSID second edition (BSID-II) for the diagnosis of moderate-to-severe neurodevelopmental impairment among infants at 12 and 18 months of age in low-resource countries.
Methods: Study participants were recruited as part of the First Bites Complementary Feeding trial from the Democratic Republic of Congo, Zambia, Guatemala and Pakistan between October 2008 and January 2011. Study participants underwent neurodevelopmental assessment by trained personnel using the ASQ and BSID-II at 12 and 18 months of age.
Results: Data on both ASQ and BSID-II assessments of 1034 infants were analysed. Four of five ASQ domains had specificities greater than 90% for severe neurodevelopmental delay at 18 months of age. Sensitivities ranged from 23% to 62%. The correlations between ASQ communications subscale and BSID-II Mental Development Index (MDI) (r=0.38) and between ASQ gross motor subscale and BSID-II Psychomotor Development Index (PDI) (r=0.33) were the strongest correlations found.
Conclusion: At 18 months, ASQ had high specificity but moderate-to-low sensitivity for BSID-II MDI and/or PDI <70. ASQ, when administered by trained healthcare workers, may be a useful screening tool to detect severe disability in infants from rural low-income to middle-income settings.
Trial Registration Number: NCT01084109.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230914 | PMC |
http://dx.doi.org/10.1136/bmjopen-2022-065076 | DOI Listing |
Arch Dis Child Fetal Neonatal Ed
January 2025
NHMRC Clinical Trials Centre, The University of Sydney, Camperdown, New South Wales, Australia.
Objective: Large-scale mortality trials require reliable secondary assessments of impairment. We compared the Ages and Stages Questionnaire (ASQ-3), a screening tool self-administered by parents, in classifying impairment using the 'gold standard' Bayley Scales of Infant Development (Bayley-III), a diagnostic tool administered by trained assessors.
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Department of Biomedical Engineering, Seoul National University College of Medicine, 103 Daehak-ro, Jongno- gu, Seoul, 03080 Republic of Korea.
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Emergency devision, Bahrami hospital, school of medicine, Tehran University of Medical Science, Tehran, Iran.
The Ages and Stages Questionnaires: Social-Emotional, Second Edition (ASQ) is a parental-report tool designed to assess the social-emotional development of young children. Its adaptation and validation in diverse cultural contexts are vital for its effective application. This study aimed to culturally adapt, validate, and standardize the ASQ for Iranian children.
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Département de Psychologie, Université de Montréal, Montréal, Québec, Canada.
Cognitive biases have been studied in relation to schizophrenia and psychosis for over 50 years. Yet, the quality of the evidence linking cognitive biases and psychosis is not entirely clear. This umbrella-review examines the quality of the evidence and summarizes the effect sizes of the reasoning and interpretation cognitive biases studied in relation to psychotic characteristics (psychotic disorders, psychotic symptoms, psychotic-like experiences or psychosis risk).
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