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Antipsychotic dopamine D affinity and negative symptoms in remitted first episode psychosis patients.
Schizophr Res
December 2024
University of Groningen, University Medical Centre Groningen, Department of Biomedical Sciences, Groningen, the Netherlands; University of Groningen, University Medical Centre Groningen, Department of Psychiatry, Groningen, the Netherlands.
Negative symptoms can be an integral part of schizophrenia spectrum pathology and can be secondary to other psychotic symptoms or caused by antipsychotic medication. As antipsychotic drugs differ in their affinity to dopamine receptors and some antipsychotics have partial agonistic effects, antipsychotic drugs are expected to vary in their ability to cause negative symptoms. The association between negative symptoms and antipsychotic medication divided into partial agonists, or antagonists with high or low D affinity was assessed in 310 remitted first episode psychosis (FEP) patients.
View Article and Find Full Text PDFMitochondrial Biomarkers and Metabolic Syndrome in Bipolar Disorder.
Psychiatry Res
September 2024
Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Mitochondrial Innovation Initiative, MITO2i, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Article Synopsis
- This study investigates the link between mitochondrial blood biomarkers, specifically lactate and circulating cell-free mitochondrial DNA, and markers of metabolic syndrome in bipolar disorder patients, hypothesizing that lactate levels would be higher in those with metabolic syndrome.
- The research involved a large cohort of 837 stable bipolar disorder patients and 237 others for validation, revealing that higher lactate levels correlated significantly with factors like triglycerides and blood pressure, indicating a strong association with metabolic syndrome.
- The findings suggest that while lactate is a key biomarker related to metabolic syndrome in bipolar patients, circulating mitochondrial DNA levels do not show this same correlation, highlighting the potential for personalized treatment strategies based on these metabolite profiles.
Expression of mGluR5 in Pediatric Hodgkin and Non-Hodgkin lymphoma-A Comparative Analysis of Immunohistochemical and Clinical Findings Regarding the Association between Tumor and Paraneoplastic Neurological Disease.
Cancers (Basel)
July 2024
NeuroCure Cluster of Excellence, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Autoantibodies targeting the neuronal antigen metabotropic glutamate receptor 5 (mGluR5) have been identified in patients with Ophelia syndrome, which describes a co-occurrence of paraneoplastic limbic encephalitis and Hodgkin lymphoma (HL). Little data exist regarding frequency and function of mGluR5 in HL and its potential role in causing seropositive paraneoplastic disease. We studied a representative cohort of pediatric HL and NHL patients (n = 57) using immunohistochemistry and fluorescence staining to investigate mGluR5 expression.
View Article and Find Full Text PDFHematologic malignancies and hematopoietic stem cell transplantation.
Handb Clin Neurol
March 2024
Department of Medicine, Hematology Unit, University of Padova, Padova, Italy.
Article Synopsis
- Paraneoplastic neurologic syndromes are uncommon in blood cancers, but lymphomas frequently show these syndromes, often lacking high-risk antibodies except in specific cases like cerebellar degeneration and limbic encephalitis.* -
- Peripheral nervous system syndromes are rare but can occur in non-Hodgkin lymphoma, with POEMS being a noteworthy rare syndrome linked to plasma cell disorders; diagnosis relies on specific criteria and VEGF levels rather than antibodies.* -
- Treatment typically involves addressing the underlying cancer, and in cases like Ophelia syndrome/limbic encephalitis with anti-mGluR5 antibodies, patients may experience full recovery; hematopoietic stem-cell transplantation is preferred for POEMS syndrome.*
A 30-year-old woman had 5 days of visual hallucinations, nystagmus, memory impairment and mutism. On examination, she was disorientated with reduced attention span, gaze-evoked nystagmus, paratonia and abnormal frontal reflexes. Cerebrospinal fluid (CSF) showed 80 cells, protein 0.
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