Direct experimental evidence for the boronic acid-mediated bridging of DNA hybrids.

Chem Commun (Camb)

Department of Biological Sciences, Birla Institute of Technology and Science (BITS), Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Medchal District, Hyderabad, Telangana - 500078, India.

Published: June 2023

AI Article Synopsis

  • This study explores the use of terminal deoxynucleotidyl transferase for the first time in understanding how boronic acid connects two DNA strands.
  • The research includes colorimetric sensing and isothermal titration calorimetry to show evidence of this connection.
  • These findings open up new possibilities and insights in the field of DNA nanobiotechnology.

Article Abstract

The use of terminal deoxynucleotidyl transferase for the first time in a mechanistic exploration-through colorimetric sensing and isothermal titration calorimetric studies-has provided direct experimental evidence of a boronic acid moiety bridging two DNA duplexes the 3' hydroxyl groups, offering new opportunities and insights into the domain of DNA (nano)biotechnology.

Download full-text PDF

Source
http://dx.doi.org/10.1039/d3cc01600eDOI Listing

Publication Analysis

Top Keywords

direct experimental
8
experimental evidence
8
evidence boronic
8
bridging dna
8
boronic acid-mediated
4
acid-mediated bridging
4
dna hybrids
4
hybrids terminal
4
terminal deoxynucleotidyl
4
deoxynucleotidyl transferase
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!