AI Article Synopsis
- Dyspnea, a common symptom in asthma, is influenced by anxiety and hyperventilation, which often occur alongside the condition.
- A study involving 142 asthmatic adults analyzed the sensory and affective aspects of dyspnea, revealing that many patients experienced severe symptoms linked to poor asthma control, hyperventilation, and anxiety.
- Results showed significant reductions in dyspnea severity after six months, highlighting the importance of addressing both hyperventilation and anxiety for better asthma management.
Article Abstract
Background: Dyspnea is a common but non-specific symptom of asthma, which in particular may be related to anxiety and hyperventilation syndrome, two frequent comorbidities of asthma.
Methods: We conducted a prospective multicentric cohort study in dyspneic asthmatic adults. Dyspnea was assessed using the Multidimensional Dyspnea Profile questionnaire. We described the sensory (QS) and affective (A2) domains of dyspnea and investigated the effect of poor asthma control, hyperventilation and anxiety on each dimension at baseline and after 6 months.
Results: We included 142 patients (65.5% women, age: 52 years). Dyspnea was severe and predominated on its sensory domain (median QS: 27/50; A2: 15/50). Uncontrolled asthma (ACQ≥1.5), hyperventilation symptoms (Nijmegen≥23) and anxiety (HAD-A≥10) were present in 75%, 45.7% and 39% of cases, respectively. Hyperventilation symptoms were associated with higher QS and A2 scores: QS at 28.4(10.7) vs. 21.7(12.8) (p = 0.001) and A2 at 24(14) vs. 11.3(11) (p < 0.001) in patients with vs. without hyperventilation symptoms. Anxiety was only associated with increased A2 (27(12.3) vs. 10.9(11), p < 0.001). At 6 months, QS and A2 decreased of 7 and 3 points, respectively, in relation with changes in ACQ-6 and Nijmegen scores as well as the HAD-A score for A2.
Conclusion: In breathless asthmatics, dyspnea is severe and worsened but differentially modulated by hyperventilation symptoms and anxiety. A multidimensional phenotyping of dyspnea in asthmatics could be useful to understand its origins and personalize treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.rmed.2023.107276 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Unexplained exertional dyspnoea without significant elevation of natriuretic peptides is common. One of the causes might be early heart failure with preserved ejection fraction (HFpEF).
Aims: This study aimed to characterize patients with exertional dyspnoea and normal/near-to-normal N-terminal pro-brain natriuretic peptide (NT-proBNP) levels with regard to early stages of HFpEF and non-cardiac causes.
Fatal Fulminant Epstein-Barr Virus (EBV) Encephalitis in Immunocompetent 5.5-Year-Old Girl-A Case Report with the Review of Diagnostic and Management Dilemmas.
Biomedicines
December 2024
Department of Pediatric Anesthesiology and Intensive Therapy, Medical University of Warsaw, 02-091 Warsaw, Poland.
Epstein-Barr virus (EBV) usually causes mild, self-limiting, or asymptomatic infection in children, typically infectious mononucleosis. The severe course is more common in immunocompromised patients. Neurological complications of primary infection, reactivation of the latent infection, or immune-mediated are well-documented.
View Article and Find Full Text PDFIn-silico simultaneous respiratory and circulatory measurement during voluntary breathing, exercise, and mental stress: A computational approach.
PLoS Comput Biol
December 2024
Human Science Research-Domain, Toyota Central R&D Labs., Inc., Nagakute, Japan.
Voluntary breathing (VB), short-term exercise (STE), and mental stress (MS) can modulate breathing rate (BR), heart rate (HR), and blood pressure (BP), thereby affecting human physical and mental state. While existing experimental studies have explored the relationship between VB, STE, or MS and BR, HR, and BP changes, their findings remain fragmented due to individual differences and challenges in simultaneous, BR, HR, and BP measurements. We propose a computational approach for in-silico simultaneous measurements of the physiological values by comprehensive prediction of the respiratory and circulatory system responses to VB, STE, or MS.
View Article and Find Full Text PDFTilt training as a treatment for reflex syncope: a multimodal approach!?
Front Neurosci
November 2024
Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Leuven, Belgium.
Purpose: Reflex syncope is a burdensome disease with considerable repercussions on the quality of life. Tilt training is a therapeutic option, but evidence on this topic is scarce and outdated. Hyperventilation is oftentimes associated with reflex syncope.
View Article and Find Full Text PDFMicroRNA-495 Modulates Neuronal Layer Fate Determination by Targeting .
Int J Biol Sci
December 2024
State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry & Molecular Biology, Medical Primate Research Center, Neuroscience Center, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China.
During cortical development, the differentiation potential of neural progenitor cells (NPCs) is one of the most critical steps in normal cortical formation and function. Defects in this process can lead to many brain disorders. MicroRNA dysregulation in the dorsolateral prefrontal cortex is associated with risk for a variety of developmental and psychiatric conditions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!