AI Article Synopsis
- Metabolic syndrome (MS) is increasingly recognized in Type 1 diabetes mellitus (T1DM) patients, which may raise the risk for diabetes-related complications, prompting this study to assess its prevalence over time in individuals with T1DM.* -
- Conducted in North India, the study involved 161 T1DM patients and found that 19.2% had MS at baseline; those with MS showed a higher likelihood of developing microvascular complications such as retinopathy, neuropathy, and nephropathy.* -
- After 5 years of follow-up, the prevalence of MS decreased to 13%, highlighting the need for early detection and targeted interventions to mitigate associated health risks for patients with T1DM.*
Article Abstract
Background And Aims: Metabolic syndrome (MS) is prevalent in the Indian population and has been traditionally linked to Type 2 diabetes mellitus (T2DM). Its presence is now being increasingly recognized in patients with Type 1 diabetes mellitus (T1DM). Presence of MS may increase the risk of diabetes related complications. This study was designed to determine the prevalence of MS in a cohort of patients with T1DM at baseline and at 5 years of follow up.
Methods: Longitudinal cohort study in a tertiary care center in North India. Patients with T1DM attending the Diabetes of the Young (DOY) Clinic from January 2015 to March 2016 included. Microvascular and macrovascular complications assessed. The cohort was followed after a period of 5 years.
Results: We included 161 patients (males, 49.4%) with a median (IQR) age of 23 (18-34) years and median (IQR) diabetes duration of 12 (7, 17) years. At baseline, 31 (19.2%) patients had MS. Patients with MS were more likely to have microvascular complications: retinopathy (p = 0.003), neuropathy (p = 0.02) and nephropathy (p = 0.04). Independent predictors of MS: insulin sensitivity (IS) (adjusted OR (aOR) 0.02 [95% CI, 0.003-0.118]), body weight (aOR 1.05 [95% CI, 1.007-1.108]), diastolic blood pressure (aOR 1.08 [95% CI, 1.01-1.15]) and duration of diabetes (aOR 1.09 [95% CI, 1.02-1.16]). On follow-up (n = 100), 13 (13%) had MS.
Conclusions: One in 5 patients with T1DM suffers from MS, and is therefore predisposed to its attendant risks, calling for early identification and targeted interventions.
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| http://dx.doi.org/10.1016/j.dsx.2023.102781 | DOI Listing |
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