The dysfunction of natural killer cells is essential for the development of type 1 diabetes.

Type 1 diabetes (T1D) is characterized by destruction of pancreatic insulin-producing beta cells by immune cells. In general, environmental and genetic factors can lead to immunological self-tolerance in TID. It is clear that the innate immune system, especially natural killer (NK) cells, is involved in the pathogenesis of T1D. Aberrant NK cell frequencies associated with dysregulation of inhibitory and activating receptors contribute to the initiation and progression of T1D. As T1D is incurable and the metabolic disturbances caused by T1D severely impact patients, a better understanding of NK cell behavior in T1D may facilitate disease treatment strategies. The current review focuses on the role of NK cell receptors in T1D and also highlights ongoing efforts to manipulate key checkpoints in NK cell-targeted therapies.