Introduction: Immune checkpoint inhibitor-mediated colitis (IMC) is commonly managed with steroids and biologics. We evaluated the efficacy of ustekinumab (UST) in treating IMC refractory to steroids plus infliximab and/or vedolizumab.
Results: Nineteen patients were treated with UST for IMC refractory to steroids plus infliximab (57.9%) and/or vedolizumab (94.7%). Most of them had grade ≥3 diarrhea (84.2%), and colitis with ulceration was present in 42.1%. Thirteen patients (68.4%) attained clinical remission with UST, and mean fecal calprotectin levels dropped significantly after treatment (629 ± 101.5 mcg/mg to 92.0 ± 21.7 mcg/mg, P = 0.0004).
Discussion: UST is a promising therapy for the treatment of refractory IMC.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098450 | PMC |
| http://dx.doi.org/10.14309/ajg.0000000000002332 | DOI Listing |
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