AI Article Synopsis

  • Sonodynamic therapy (SDT) utilizes sonosensitizers to produce reactive oxygen species using ultrasound, but it relies on oxygen levels and imaging tools for effectiveness.
  • Photoacoustic imaging (PAI) serves as a crucial noninvasive tool that measures tumor oxygen saturation and helps guide SDT treatment, including recent advancements in exogenous contrast agents and nanomaterials.
  • While PAI-guided SDT offers promising cancer treatment potential, challenges like complex designs, high production costs, and the need for more research impede its clinical application, demanding collaboration across various fields for successful implementation.

Article Abstract

Sonodynamic therapy (SDT) is a promising approach for cancer treatment that uses sonosensitizers (SNSs) to generate reactive oxygen species (ROS) in the presence of ultrasound (US). However, SDT is oxygen-dependent and requires an imaging tool to monitor the tumor microenvironment and guide treatment. Photoacoustic imaging (PAI) is a noninvasive and powerful imaging tool that offers high spatial resolution and deep tissue penetration. PAI can quantitatively assess tumor oxygen saturation (sO2) and guide SDT by monitoring time-dependent sO2 changes in the tumor microenvironment. Here, we discuss recent advances in PAI-guided SDT for cancer therapy. We discuss various exogenous contrast agents and nanomaterial-based SNSs developed for PAI-guided SDT. Additionally, combining SDT with other therapies, including photothermal (PTT) therapy, can enhance its therapeutic effect. However, the application of nanomaterial-based contrast agents in PAI-guided SDT for cancer therapy remains challenging due to the lack of simple designs, the need for extensive pharmacokinetic studies, and high production costs. Integrated efforts from researchers, clinicians, and industry consortia are necessary for the successful clinical translation of these agents and SDT for personalized cancer therapy. PAI-guided SDT shows the potential to revolutionize cancer therapy and improve patient outcomes, but further research is necessary to realize its full potential.

Download full-text PDF

Source
http://dx.doi.org/10.1109/TUFFC.2023.3277283DOI Listing

Publication Analysis

Top Keywords

pai-guided sdt
16
cancer therapy
16
sdt
9
personalized cancer
8
sonodynamic therapy
8
imaging tool
8
tumor microenvironment
8
sdt cancer
8
contrast agents
8
therapy
7

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!