AI Article Synopsis
- Angiogenesis is a crucial process for development, growth, and healing, but when it goes wrong, it is linked to diseases like cancer.
- New tools, such as code scripts (AngiogenesisAnalyzer.ijm, AutomaticMeasure.ijm, and VM.R.), have been created to study angiogenesis dynamically rather than just through static snapshots.
- These tools have been used to test drugs that can alter how quickly blood vessels form, with animal studies showing that some of these drugs can successfully inhibit new blood vessel formation.
Article Abstract
New vessel formation (angiogenesis) is an essential physiological process for embryologic development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the molecular level. Dysregulation of angiogenesis occurs in various pathologies and is one of the hallmarks of cancer. However, most existing methods for evaluating cell vascular formation are limited to static analysis and prone to bias due to time, field of vision, and parameter selection. Code scripts, such as AngiogenesisAnalyzer.ijm, AutomaticMeasure.ijm, and VM.R., were developed to study the dynamic angiogenesis process. This method was used to screen drugs that could affect the time, maximum value, tilt, and decline rate of cell vascular formation and angiogenesis. Animal experiments have confirmed that these drugs could inhibit the formation of blood vessels. This work provides a new perspective for the research of angiogenesis process and is helpful to the development of drugs related to angiogenesis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193242 | PMC |
| http://dx.doi.org/10.1016/j.isci.2023.106721 | DOI Listing |
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