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A rare case of mucoepidermoid carcinoma ex-pleomorphic adenoma of the hard palate. | LitMetric

AI Article Synopsis

  • Carcinoma Ex-Pleomorphic Adenoma (CExPA) is a rare type of salivary gland cancer that develops from a benign pleomorphic adenoma and is particularly uncommon in minor salivary glands.
  • A case study is presented involving a 37-year-old male patient with a fast-growing palatal lesion, which had evolved over two years and caused pain and ulceration in the last couple of months.
  • The diagnosis of CExPA was confirmed through biopsy and immunohistochemical analysis, and the paper discusses the histopathological features and diagnostic criteria to help improve understanding of this unusual malignant tumor.

Article Abstract

Carcinoma Ex-Pleomorphic Adenoma (CExPA) is a salivary gland carcinoma derived from a primary or recurrent benign pleomorphic adenoma (PA) extremely rare in minor salivary glands. In this paper, we report the case of a male afrodescendant patient, 37 years old, presenting a palatal irregular nodular lesion with approximately 3.5 cm diameter. The lesion had over two years of evolution, but started growing faster and presenting pain and ulceration in the last two months. The incisional biopsy revealed a typical pleomorphic adenoma with focal areas of nests of epidermoid and mucous cells, as well as microcyst formations, resembling the mucoepidermoid carcinoma (MEC). Immunohistochemical analysis revealed positivity for CK7, CK13, CK 14, p63 and Ki67 (about 30%), whereas α-SMA was restricted to the PA component. The diagnosis was CExPA (MEC-type). A discussion on the histopathological and immunohistochemical criteria for differential diagnosis of CExPA is provided in this work, hoping to contribute to a better knowledge and understanding of this rare malignant tumor. Salivary gland neoplasms, pleomorphic adenoma, adenocarcinoma, mucoepidermoid carcinoma, pathology, differential diagnosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198693PMC
http://dx.doi.org/10.4317/jced.59982DOI Listing

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