Background: () infection is a global problem, causing significant morbidity and mortality. Furazolidone is recommended to eradicate infections in China owing to the highly associated antibiotic resistance.
Case Summary: This article presents two cases of lung injury caused by furazolidone treatment of infection and the relevant literature review. Two patients developed symptoms, including fever, cough, and fatigue after receiving a course of furazolidone for infection. Chest computed tomography showed bilateral interstitial infiltrates. Laboratory studies revealed elevated blood eosinophil count. After discontinuing furazolidone with or without the use of corticosteroids, the symptoms improved rapidly. A PubMed database literature search revealed three reported cases of lung injury suggestive of furazolidone-induced pulmonary toxicity.
Conclusion: Clinicians should be aware of the side effects associated with the administration of furazolidone to eradicate infection.
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http://dx.doi.org/10.12998/wjcc.v11.i12.2832 | DOI Listing |
World J Clin Cases
April 2023
Geriatric Medicine Center, Department of Pulmonary and Critical Care Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China.
Background: () infection is a global problem, causing significant morbidity and mortality. Furazolidone is recommended to eradicate infections in China owing to the highly associated antibiotic resistance.
Case Summary: This article presents two cases of lung injury caused by furazolidone treatment of infection and the relevant literature review.
Ann Pharmacother
February 2005
Division of Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA.
Objective: To report a case of pulmonary hypersensitivity associated with furazolidone use and review the literature on this topic.
Case Summary: A 43-year-old white female presented with fever and dyspnea. She had recently completed a course of furazolidone 125 mg 4 times daily for 10 days for enteritis.
Acta Vet Hung
March 1994
National Food Investigation Institute, Budapest, Hungary.
Furazolidone (F) and its 5-nitrofuran derivatives, occasionally used in veterinary and human medicine, are active against some microorganisms. This drug is considered to be mutagenic in special bacterial test systems. For public health reasons, the presence of F and other 5-nitrofuran residues in edible mammalian and poultry tissues is strictly prohibited.
View Article and Find Full Text PDFAm J Vet Res
September 1991
Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
Clinical and pathologic alterations during the development of furazolidone-induced toxicosis were investigated in a group of 35 newly hatched male Pekin ducklings fed a ration containing 700 mg of furazolidone/kg of feed for 27 days. A control group (n = 25) was fed the same ration without added furazolidone. Every 3 days, ducklings were weighted and palpated for ascites and 3 were chosen at random for euthanasia to determine the severity of lesions and to obtain hearts for gross measurements and ultrastructural study.
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