Furazolidone-induced pulmonary toxicity in infection: Two case reports.

World J Clin Cases

Geriatric Medicine Center, Department of Pulmonary and Critical Care Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China.

Published: April 2023

Background: () infection is a global problem, causing significant morbidity and mortality. Furazolidone is recommended to eradicate infections in China owing to the highly associated antibiotic resistance.

Case Summary: This article presents two cases of lung injury caused by furazolidone treatment of infection and the relevant literature review. Two patients developed symptoms, including fever, cough, and fatigue after receiving a course of furazolidone for infection. Chest computed tomography showed bilateral interstitial infiltrates. Laboratory studies revealed elevated blood eosinophil count. After discontinuing furazolidone with or without the use of corticosteroids, the symptoms improved rapidly. A PubMed database literature search revealed three reported cases of lung injury suggestive of furazolidone-induced pulmonary toxicity.

Conclusion: Clinicians should be aware of the side effects associated with the administration of furazolidone to eradicate infection.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198096PMC
http://dx.doi.org/10.12998/wjcc.v11.i12.2832DOI Listing

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