AI Article Synopsis
- Papillary thyroid cancer (PTC) is a type of thyroid tumor that rarely spreads to the skin but, when it does, leads to poor survival rates.
- A patient with scalp metastasis from PTC showed a significant reduction in tumor sizes after receiving three cycles of anlotinib, a medication usually used for other advanced cancers.
- Anlotinib continued after surgery further decreased tumor size, suggesting it could effectively treat similar cases of cancer metastasis in the future.
Article Abstract
Background: Papillary thyroid cancer (PTC) is one of the well-differentiated thyroid tumors. Cutaneous metastasis from differentiated thyroid cancers occurs in < 1% of primary thyroid carcinomas but produces the worst survival prognosis. The multi-targeting tyrosine kinase inhibitor anlotinib has been approved to treat refractory advanced non-small-cell lung cancer as well as advanced soft-tissue and clear cell sarcomas in China.
Case Summary: In a patient with scalp metastasis caused by PTC, thyroid and skull metastasis tumor sizes were significantly reduced after a trial of neoadjuvant anlotinib therapy for 3 cycles. Anlotinib maintenance medication after thyroidectomy further reduced the metastatic skull tumor size thereby preventing the requirement for craniotomy.
Conclusion: The outcome of the present trial confirmed the potential of anlotinib therapy to treat scalp metastasis induced by PTC and point the way for the treatment of similar diseases in the future.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198115 | PMC |
| http://dx.doi.org/10.12998/wjcc.v11.i12.2839 | DOI Listing |
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