Human-in-the-loop optimization has made great progress to improve the performance of wearable robotic devices and become an effective customized assistance strategy. However, a lengthy period (several hours) of continuous walking for iterative optimization for each individual makes it less practical, especially for disabled people, who may not endure this process. In this paper, we provide a muscle-activity-based human-in-the-loop optimization strategy that can reduce the time spent on collecting biosignals during each iteration from around 120 s to 25 s. Both Bayesian and Covariance Matrix Adaptive Evolution Strategy (CMA-ES) optimization algorithms were adopted on a portable hip exoskeleton to generate optimal assist torque patterns, optimizing rectus femoris muscle activity. Four volunteers were recruited for exoskeleton-assisted walking trials. As a result, using human-in-the-loop optimization led to muscle activity reduction of 33.56% and 41.81% at most when compared to walking without and with the hip exoskeleton, respectively. Furthermore, the results of human-in-the-loop optimization indicate that three out of four participants achieved superior outcomes compared to the predefined assistance patterns. Interestingly, during the optimization stage, the order of the two typical optimizers, i.e., Bayesian and CMA-ES, did not affect the optimization results. The results of the experiment have confirmed that the assistance pattern generated by muscle-activity-based human-in-the-loop strategy is superior to predefined assistance patterns, and this strategy can be achieved more rapidly than the one based on metabolic cost.
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http://dx.doi.org/10.3389/fbioe.2023.1006326 | DOI Listing |
Wearable Technol
November 2024
BruBotics, Vrije Universiteit Brussel, Brussels, 1050, Belgium.
Advancements in wearable robots aim to improve user motion, motor control, and overall experience by minimizing energetic cost (EC). However, EC is challenging to measure and it is typically indirectly estimated through respiratory gas analysis. This study introduces a novel EMG-based objective function that captures individuals' natural energetic expenditure during walking.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany.
Despite the significant advancements of liver surgery in the last few decades, the survival rate of patients with liver and pancreatic cancers has improved by only 10% in 30 years. Precision medicine offers a patient-centered approach, which, when combined with machine learning, could enhance decision making and treatment outcomes in surgical management of ihCC. This study aims to develop a decision support model to optimize treatment strategies for patients with ihCC, a prevalent primary liver cancer.
View Article and Find Full Text PDFJACS Au
November 2024
Department of Chemical Engineering, Loughborough University, Loughborough LE11 3TU, U.K.
This study leverages and upgrades the capabilities of computer-aided retrosynthesis (CAR) in the systematic development of greener and more efficient total synthetic routes for the active pharmaceutical ingredient (API) IM-204, a helicase-primase inhibitor that demonstrated enhanced efficacy against Herpes simplex virus (HSV) infections. Using various CAR tools, several total synthetic routes were uncovered, evaluated, and experimentally validated, with the goal to maximize selectivity and yield and minimize the environmental impact. The CAR tools revealed several synthetic options under different constraints, which can overperform the patented synthetic route used as a reference.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Changzhou Vocational Institute of Industry Technology, Changzhou 213164, China.
Soft exoskeletons (exosuits) are expected to provide a comfortable wearing experience and compliant assistance compared with traditional rigid exoskeleton robots. In this paper, an exosuit with twisted string actuators (TSAs) is developed to provide high-strength and variable-stiffness actuation for hemiplegic patients. By formulating the analytic model of the TSA and decoding the human impedance characteristic, the human-exosuit coupled dynamic model is constructed.
View Article and Find Full Text PDFJ Cheminform
December 2024
Department of Computer Science, Aalto University, 02150, Espoo, Finland.
Machine learning (ML) systems have enabled the modelling of quantitative structure-property relationships (QSPR) and structure-activity relationships (QSAR) using existing experimental data to predict target properties for new molecules. These property predictors hold significant potential in accelerating drug discovery by guiding generative artificial intelligence (AI) agents to explore desired chemical spaces. However, they often struggle to generalize due to the limited scope of the training data.
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