Antifungal properties of (2S, 4R)-Ketoconazole sulfonamide analogs.

Invasive candidiasis remains a significant health concern, as it is associated with a high mortality risk. In addition, the risk of infection is significantly elevated in immunocompromised patients such as those with HIV, cancer, or those taking imcmunosuppressive drugs as a result of organ transplantation. The majority of these cases are caused by , and is the second most common cause. These infections are typically treated using approved antifungal agents, but the rise of drug-resistant fungi is a serious concern. As part of our on-going effort to identify novel antifungal agents, we have studied the antifungal properties of a series of sulfonamide analogs of (2S, 4R)-Ketoconazole. Herein we report on the activity against the key fungal pathogens , and .