Antibiotic resistance characteristics and risk factors analysis of strains isolated from patients in Liaoning Province, an area in North China.

Background: The prevalence of () keeps rising while the eradication rate continues to decline due to the increasing antibiotic resistance. Regional variations of antimicrobial resistance to have been recommended by guidelines in recent years. This study aims to investigate the antibiotic resistance rate of and its association with infected subjects' characteristics in Liaoning Province, an area in north China.

Methods: Gastric tissues from 178 positive participants without previous antibiotic use within four weeks were collected for culture. Antibiotic susceptibility to furazolidone (AOZ), tetracycline (TC), levofloxacin (LFX), metronidazole (MET), clarithromycin (CLA), and amoxicillin (AMX) were examined with the agar dilution method. Associations between resistance and patient characteristics were further analysed.

Results: No resistance was observed in AOZ or TC. For LFX, MET, CLA, and AMX, the overall resistance rates were 41.10%, 79.14%, 71.78%, and 22.09% respectively. There were significant differences between resistance to CLA and MALToma ( = 0.021), and between resistance to MET and age ( < 0.001).

Conclusions: The primary resistant rates of LEX, MET, CLA, and AMX were relatively high in Liaoning. Treatment effectiveness improvement could be achieved by prior antimicrobial susceptibility tests before antibiotic prescription.