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| http://dx.doi.org/10.1001/jamainternmed.2023.0777 | DOI Listing |
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Alzheimers Dement
December 2024
Boston University Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Background: There is growing evidence that epigenetic age acceleration may predict late life cognitive decline and dementia, but it is unknown whether this is due to accelerated neurodegeneration or reduction in cognitive resilience. We examined the relationship between epigenetic clocks and domain specific neuropsychological (NP) factor scores, mild cognitive impairment (MCI), Alzheimer's Disease (AD), and all-cause dementia, before and after accounting for plasma total tau (t-tau), a marker of neurodegeneration.
Method: DNA methylation and plasma t-tau (Simoa assay; Quanterix) data from 2091 Framingham Heart Study Offspring cohort participants were generated from blood at the same Exam 8 visit (2005-2008).
Social support and aging: psychometric analysis of the ENRICHD Social Support Instrument in a Chilean population over 50.
Psicol Reflex Crit
January 2025
Departamento de Psicología. Facultad de Educación, Ciencias Sociales y Humanidades, Universidad de La Frontera, Temuco, Chile.
Background: Social support is relevant to studying well-being, quality of life, and health during aging, particularly in people over 50. Therefore, brief instruments that allow its measurement within the clinical evaluation and research processes are necessary. The ENRICH Social Support Scale (ESSI) is a brief and easy-to-use instrument that measures the perception of social support; however, its psychometric properties in people over 50 in the Chilean context have yet to be tested.
View Article and Find Full Text PDFSemiquantitative 2-[F]FDG PET/CT-based parameters role in lymphoma.
Front Med (Lausanne)
December 2024
Dipartimento di Radiodiagnostica e Radioterapia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
2-deoxy-2-[F]-fluoro-D-glucose (2-[F]FDG) positron emission tomography/computed tomography (PET/CT) plays a crucial role in the management of lymphoma in different settings, such as staging disease, assessing response to therapy, predicting prognosis, and planning RT. Beside visual analysis, several semiquantitative parameters were introduced to study lymphoma with promising results. These parameters can represent different disease characteristics, like body composition (such as sarcopenic index), dissemination of disease (Dmax), tumor burden (including metabolic tumor volume) and texture features.
View Article and Find Full Text PDFMeasuring habituation to stimuli: The Italian version of the Sensory Habituation Questionnaire.
PLoS One
December 2024
Department of Psychology, Educational Sciences and Human Movement, University of Palermo, Palermo, Italy.
Sensory habituation allows us to decrease responsiveness to repetitive or prolonged stimuli over time, making them easy to filter out and not interfere with ongoing activities. As such, habituation could be an important aspect to be evaluated within a sensory and cognitive assessment. The main aim of the present study was to validate an Italian version of the Sensory Habituation Questionnaire (S-Hab-Q), a self-report tool assessing how long an adult individual takes to adapt to daily sensory stimuli.
View Article and Find Full Text PDFLongitudinal Measurement Invariance of the Parenting Sense of Competence (PSoC): Evidence to Question Its Use?
Child Care Health Dev
January 2025
Department of Health Sciences, University of York, England, UK.
Background: This study investigated the factor structure of the parenting sense of competence (PSoC), a measure of parenting self-efficacy, in a sample of parents recruited when their infants were under 2 months old. Due to the lack of longitudinal analysis of the PSoC's factor structure over time, the study sought to establish if the published two-factor structure was consistent over an 18-month period.
Methods: Data collected from 536 parents who had participated in a randomised controlled trial of universal proportionate parenting support, delivered in five sites in England, were subject to confirmatory factor analysis (CFA).
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