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Comparison of Drug Delivery Systems with Different Types of Nanoparticles in Terms of Cellular Uptake and Responses in Human Endothelial Cells, Pericytes, and Astrocytes.
Pharmaceuticals (Basel)
November 2024
Department of Histology and Embryology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul 34098, Turkey.
: The key components of the blood-brain barrier (BBB) are endothelial cells, pericytes, astrocytes, and the capillary basement membrane. The BBB serves as the main barrier for drug delivery to the brain and is the most restrictive endothelial barrier in the body. Nearly all large therapeutic molecules and over 90% of small-molecule drugs cannot cross the BBB.
View Article and Find Full Text PDFMorphological Features of the Pecten Oculi in the Common Kestrel (Falco tinnunculus).
Anat Histol Embryol
January 2025
Department of Biochemistry, Yozgat Bozok University, Faculty of Veterinary Medicine, Yozgat, Turkey.
This study aimed to investigate the macroscopic, light microscopic (LM) and scanning electron microscopic (SEM) characteristics of the pecten oculi in common kestrels (Falco tinnunculus). A total of six eyeballs from three common kestrels were used as the study material. The examination revealed that the bulbus oculi was spherical in shape and its diameter exceeded the axial-global length.
View Article and Find Full Text PDFThe triple combination DBDx alleviates cytokine storm and related lung injury.
Int Immunopharmacol
December 2024
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Cytokine storm is a life-threatening disorder, and therapeutic treatments are urgently needed. Here, we investigated the anti-cytokine storm efficacy of DBDx, a triple drug combination composed of dipyridamole, ubenimex and dexamethasone. Evaluated by lipopolysaccharide (LPS)-induced cytokine storm murine model, DBDx significantly improved survival rate and prolonged survival time of the model mice.
View Article and Find Full Text PDFDistinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species.
JCI Insight
September 2024
Department of Medicine and.
Lipoprotein lipase (LPL) and multiple regulators of LPL activity (e.g., APOC2 and ANGPTL4) are present in all vertebrates, but GPIHBP1-the endothelial cell (EC) protein that captures LPL within the subendothelial spaces and transports it to its site of action in the capillary lumen-is present in mammals but in not chickens or other lower vertebrates.
View Article and Find Full Text PDFInvolvement of the Kinin B1 Receptor in Increased Permeability of Cerebral Microvessels in Rats Subjected to Autoimmune Encephalomyelitis.
Cells
October 2024
Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Institute, Polish Academy of Sciences, 5 A. Pawińskiego str., 02-106 Warsaw, Poland.
Kinins are vasoactive peptides that are involved in various cellular mechanisms, including the inflammatory response. Kinins, released in vessel walls, exacerbate inflammation by modulating the production and release of pro-inflammatory factors via two types of G protein-related receptors-B1 and B2 receptors. B1 R is overexpressed during the inflammation that accompanies numerous neurological disorders, including multiple sclerosis (MS), in which loss of BBB integrity is an early pathomechanism of the disease.
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