We conducted a megastudy to examine the spelling of American English monosyllables with typewritten responses. We related both sublexical and lexical/semantic factors to spelling accuracy and reaction time (RT) for the first keypress and response duration for spelling 1,856 monophonic monosyllables. We found that (a) each of 13 predictor variables was significantly related to performance for at least one measure, (b) orthographic length was unrelated to the first key RT, but did relate to accuracy and response duration, (c) sound-spelling and spelling-sound consistency was related to performance, and in particular, onset consistency related to accuracy and first key RT, but was unrelated to response duration, (d) contextual diversity was consistently related to performance across all measures, and (e) age of acquisition (AoA) was related to all measures, but was related more to the first key RT than response duration. The results indicate that people begin the spelling process once they identify the first letter, and they continue to process the spelling pattern as the response unfolds. These results are best explained by a parallel-distributed-processing framework.
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http://dx.doi.org/10.1177/17470218231178507 | DOI Listing |
Geroscience
January 2025
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Cellular senescence is a phenotypic state that contributes to the progression of age-related disease through secretion of pro-inflammatory factors known as the senescence-associated secretory phenotype (SASP). Understanding the process by which healthy cells become senescent and develop SASP factors is critical for improving the identification of senescent cells and, ultimately, understanding tissue dysfunction. Here, we reveal how the duration of cellular stress modulates the SASP in distinct subpopulations of senescent cells.
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January 2025
Department of Hematology, Kanghua Hospital, Dongguan, Guangdong, P.R. China.
The efficacy and safety of total marrow irradiation (TMI) plus a reduced dose of melphalan as autologous stem cell transplantation (ASCT) preconditioning for multiple myeloma (MM) patients were evaluated. The 11 patients with MM had a median age of 57 (range: 46-75) years; six of them were at standard risk and five of them were at high risk based on the Mayo Stratification of Myeloma and Risk-adapted Therapy (mSMART) standard risk factors. Before ASCT, three patients achieved stringent complete response (sCR), two patients achieved complete remission (CR), and the rest of the patients had either partial response (PR) or progressive disease.
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January 2025
Plant Science and Biotechnology Research Group, School of Life Sciences and Technology, Institut Teknologi Bandung, West Java, 40132, Indonesia.
Agarwood is a highly prized resinous wood produced by select members of the Thymelaeaceae plant family. Its formation in Aquilaria species has been expedited using various induction techniques, revealing insights into factors affecting the chemical constituents of artificially induced agarwood. Building on this, our research delved into the potential of another Thymelaeaceae member, Gyrinops versteegii, as an alternate agarwood source.
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January 2025
Amity Institute of Environmental Sciences (AIES), Amity University Uttar Pradesh (AUUP), Sector-125, Gautam Budh Nagar, Noida, 201313, India.
This study focused on simulating the adsorption-based separation of Methylene Blue (MB) dye utilising Oryza sativa straw biomass (OSSB). Three distinct modelling approaches were employed: artificial neural networks (ANN), adaptive neuro-fuzzy inference systems (ANFIS), and response surface methodology (RSM). To evaluate the adsorbent's potential, assessments were conducted using Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
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January 2025
The Department of Cellular and Integrative Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Fragile X syndrome (FXS) is a neurodevelopmental disorder oftentimes associated with abnormal social behaviors and altered sensory responsiveness. It is hypothesized that the inappropriate filtering of sensory stimuli, including olfaction, can lead to aberrant social behavior in FXS. However, previous studies investigating olfaction in animal models of FXS have shown inconsistent results.
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