School of Biological and Chemical Sciences, SSPC - The SFI Research Centre for Pharmaceuticals, University of Galway, University Road, Galway, Ireland. Electronic address:
Published: July 2023
AI Article Synopsis
Article Abstract
1-Deoxynojirimycin (1-DNJ) is a glycoprocessing inhibitor, and it serves as a synthetic precursor to two of three currently marketed iminosugar drugs, miglustat (N-butyl DNJ/Zavesca®) and miglitol (Glyset®). Herein a continuous flow procedure is presented that shortens a synthesis of 1-DNJ from an intermediate prepared from l-sorbose. Batch reactions involving an azide reduction, subsequent reductive amination-based cyclisation, and O-benzyl deprotection in a previous report required two steps and the use of an acid. Here, this sequence is achieved in one step using the H-Cube® MiniPlus continuous flow reactor. Subsequent reductive amination of 1-DNJ with butanal using the H-Cube® gave NB-DNJ.
We report a scalable method based on continuous-flow reactors for conformally coating the surfaces of facet-controlled Pd nanocrystals with uniform, ultrathin shells made of Pt. The key to the success of such an approach is the identification of a proper polyol to generate the Pt atoms at a relatively slow rate to ensure adequate surface diffusion and thus the formation of uniform shells in a layer-by-layer fashion. We first demonstrate the concept using the production of Pd@Pt (n = 2-5) core-shell icosahedral nanocrystals and then have the strategy successfully extended to the syntheses of Pd@Pt cubic and octahedral nanocrystals.
Introduction: Carbonated water (CarbW) affects the swallowing function associated with the action of the brainstem. In addition, CarbW ingestion promotes mean blood flow in the middle cerebral artery, which is associated with blood flow to the frontal and temporal lobes. In this milieu, studies regarding the effect of drinking CarbW on brain activity are of significance.
Extreme Materials Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; Korea Institute of Science and Technology - Sungkyunkwan University Carbon-Neutral Research Center, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea; School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea. Electronic address:
Oil spill accidents have series environmental and economic impacts, increasing the demand for efficient technologies to recover oil from contaminated waters. In this study, a hierarchically structured ratchet surface with superhydrophilicity was presented as a novel oil skimming mechanism for the recovery of high-viscosity oil, particularly low-sulfur fuel oil (LSFO), which has recently been used as marine fuel in open water environments. The interaction between the superhydrophilic ratchet and oil provides favorable conditions for oil retention at the water surface.
Background: Chronic arterial hypertension restructures the vascular architecture of the brain, leading to a series of pathological responses that culminate in cerebral small-vessel disease. Pericytes respond dynamically to vascular challenges; however, how they manifest under the continuous strain of hypertension has not been elucidated.
Methods And Results: In this study, we characterized pericyte behavior alongside hypertensive states in the spontaneously hypertensive stroke-prone rat model, focusing on their phenotypic and metabolic transformation.
Neuroimmunology Program, Fundació Clínic per la Recerca Biomèdica - Institut d'Investigacions Biomèdiques August Pi i Sunyer (FCRB-IDIBAPS), Barcelona 08036, Spain.
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a disorder mediated by autoantibodies against the GluN1 subunit of NMDAR. It occurs with severe neuropsychiatric symptoms that often improve with immunotherapy. Clinical studies and animal models based on patients' antibody transfer or NMDAR immunization suggest that the autoantibodies play a major pathogenic role.
