AI Article Synopsis
- Enhanced adipogenic differentiation of mesenchymal stem cells (MSCs) is a key factor in the development of steroid-induced osteonecrosis of the femoral head (SONFH).
- Research showed that miR-486-5p levels were significantly lower in both SONFH patients and rat models, indicating a potential role in the disease process.
- The study found that miR-486-5p inhibits adipogenesis in stem cells and fat formation in the femoral head, suggesting it may be a promising target for treatment of SONFH.
Article Abstract
Enhanced adipogenic differentiation of mesenchymal stem cells (MSCs) is considered as a major risk factor for steroid-induced osteonecrosis of the femoral head (SOFNH). The role of microRNAs during this process has sparked interest. miR-486-5p expression was down-regulated significantly in femoral head bone tissues of both SONFH patients and rat models. The purpose of this study was to reveal the role of miR-486-5p on MSCs adipogenesis and SONFH progression. The present study showed that miR-486-5p could significantly inhibit adipogenesis of 3T3-L1 cells by suppressing mitotic clonal expansion (MCE). And upregulated expression of P21, which was caused by miR-486-5p mediated TBX2 decrease, was responsible for inhibited MCE. Further, miR-486-5p was demonstrated to effectively inhibit steroid-induced fat formation in the femoral head and prevented SONFH progression in a rat model. Considering the potent effects of miR-486-5p on attenuating adipogenesis, it seems to be a promising target for the treatment of SONFH.
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| http://dx.doi.org/10.1093/stmcls/sxad038 | DOI Listing |
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