Electronic health records (EHR) are sparse, noisy, and private, with variable vital measurements and stay lengths. Deep learning models are the current state of the art in many machine learning domain; however, the EHR data is not a suitable training input for most of them. In this paper, we introduce RIMD, a novel deep learning model that consists of a decay mechanism, modular recurrent networks, and a custom loss function that learns minor classes. The decay mechanism learns from patterns in sparse data. The modular network allows multiple recurrent networks to pick only relevant input based on the attention score at a given timestamp. Finally, the custom class balance loss function is responsible for learning minor classes based on samples provided in training. This novel model is used to evaluate predictions for early mortality identification, length of stay, and acute respiratory failure on MIMIC-III dataset. Experiment results indicate that the proposed models outperform similar models in F1-Score, AUROC, and PRAUC scores.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.artmed.2023.102526 | DOI Listing |
Nutrients
November 2024
Laboratory of Host Defense, Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan.
Metabolic-dysfunction-associated steatotic liver disease (MASLD) is a progressive liver disorder that possesses metabolic dysfunction and shows steatohepatitis. Although the number of patients is globally increasing and many clinical studies have developed medicine for MASLD, most of the studies have failed due to low efficacy. One reason for this failure is the lack of appropriate animal disease models that reflect human MASLD to evaluate the potency of candidate drugs.
View Article and Find Full Text PDFmBio
November 2024
Department of Microbiology, Faculty of Medicine, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Yamanashi, Japan.
We previously reported that hepatitis C virus (HCV) infection or HCV core protein expression induces HOX gene expression by impairing histone H2A monoubiquitination via a proteasome-dependent reduction in the level of RNF2, a key catalytic component of polycomb repressive complex 1 (H. Kasai, K. Mochizuki, T.
View Article and Find Full Text PDFBrief Bioinform
July 2024
Department of Systems Immunology, Immunology Frontier Research Institute (IFReC), Osaka University, 3-1 Yamadaoka, Suita 565-0871, Japan.
Liquid biopsies based on peripheral blood offer a minimally invasive alternative to solid tissue biopsies for the detection of diseases, primarily cancers. However, such tests currently consider only the serum component of blood, overlooking a potentially rich source of biomarkers: adaptive immune receptors (AIRs) expressed on circulating B and T cells. Machine learning-based classifiers trained on AIRs have been reported to accurately identify not only cancers but also autoimmune and infectious diseases as well.
View Article and Find Full Text PDFSci Rep
August 2024
Laboratory of Clinical Research on Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Coronavirus (CoV) possesses numerous functional cis-acting elements in its positive-strand genomic RNA. Although most of these RNA structures participate in viral replication, the functions of RNA structures in the genomic RNA of CoV in viral replication remain unclear. In this study, we investigated the functions of the higher-order RNA stem-loop (SL) structures SL5B, SL5C, and SL5D in the ORF1a coding region of Middle East respiratory syndrome coronavirus (MERS-CoV) in viral replication.
View Article and Find Full Text PDFInt J Syst Evol Microbiol
May 2024
Department of Infection Metagenomics, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!