AI Article Synopsis
- Superoxide dismutase (SOD) is a powerful antioxidant used in foods, cosmetics, and therapies, but its oral delivery is problematic due to instability and low absorption in the digestive system.
- Researchers developed a highly stable version of SOD (hsSOD) from a hot spring microbial sample that maintains its activity even in harsh GI conditions.
- The effectiveness of hsSOD in combating skin aging was tested in lab and mouse models, showing potential for broader use in health-related products.
Article Abstract
As an effective antioxidant enzyme, superoxide dismutase (SOD) has been widely used as a food supplement, cosmetic additive, and therapeutic agent. However, oral delivery of SOD is challenging due to its relative instability, limited bioavailability, and low absorption efficiency in the gastrointestinal (GI) tract. We addressed these issues using a highly stable superoxide dismutase (hsSOD) generated from a hot spring microbial sample. This SOD exhibited a specific activity of 5000 IU/mg while retaining its enzymatic activity under low pH environments of an artificial GI system and in the presence of surfactants and various proteolytic enzymes. The inhibitory effects of hsSOD against skin-aging was evaluated under both in vitro and in vivo experiments using fibroblast cell and D-galactose induced aging-mouse models, respectively. Effective oral delivery of hsSOD promises wide applicability in pharmaceutical and food industries.
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| http://dx.doi.org/10.1016/j.biopha.2023.114878 | DOI Listing |
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