To analyse the fetal dose in all three trimesters in patients treated for brain tumors during pregnancy, a modified rando phantom representing three different trimesters was used with provisions for insertion of ion-chamber and Optically Simulated Luminescence Dosimeter (OSLD). The measurement regions were chosen at the level of fundus, umbilicus and pubis. Seven different treatment plans with 6FF and 6FFF beam energies were generated. Treating pregnant patients with brain tumors is safe irrespective of planning modalities except 3DCRT plan where the dose is 10.24 cGy.
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http://dx.doi.org/10.1016/j.apradiso.2023.110854 | DOI Listing |
J Appl Toxicol
March 2025
Department of Environment and Public Health, National Institute for Minamata Disease, Minamata, Kumamoto, Japan.
Despite the high frequency of pregnancies complicated by abnormal glucose metabolism associated with obesity, methylmercury (MeHg) metabolism in pregnant women with abnormal glucose metabolism is unclear. We aimed to elucidate the MeHg tissue distribution in obese female mice with abnormal glucose metabolism and their fetuses. Female C57BL/6J mice were fed a high-fat diet (HFD) or a standard diet (Ctrl) for 12 weeks and mated.
View Article and Find Full Text PDFMedicine (Baltimore)
March 2025
Ataturk University School of Medicine, Department of Anaesthesiology and Reanimation, Erzurum, Turkey.
Background: Providing effective labor analgesia is very important for maternal and infant safety. Various neuraxial techniques are used for this purpose. Our objective was to compare the epidural volume extension (EVE) and dural puncture epidural (DPE) procedures employed in clinical practice for labor analgesia, focusing on labor parameters, pain levels, fetal outcomes, and complications.
View Article and Find Full Text PDFFront Cell Dev Biol
February 2025
Department of Medical and Surgical Science of Infant and Adult, University of Modena and Reggio Emilia, Modena, Italy.
Background: In the human placenta, we have detected the MPs by Raman microspectroscopy analysis and, for the first time, with transmission electron microscopy. MPs fragments have been localized in different compartments of placental tissue, free in the cytoplasm and within organelles like lysosomes. Moreover, their presence has been correlated with ultrastructural alterations of some cell organelles, typical of metabolic stress, mainly dilated rough endoplasmic reticulum and numerous swollen electrodense mitochondria, as well as signs derived from involuting organelles.
View Article and Find Full Text PDFCureus
February 2025
Pediatrics, Saint Peter's University Hospital, New Brunswick, USA.
Neuroimaging of cerebral neoplastic lesions and post-radiation necrosis (PRN) presents significant challenges due to their overlapping features, making differentiation difficult. The use of various imaging modalities in association with radiation therapy introduces potential risks and prognostic variations that can affect lesion physiology. Patients who undergo radiation treatment inevitably experience changes influenced by factors such as radiation dose, brain volume, and tumor fraction size.
View Article and Find Full Text PDFClin Rheumatol
March 2025
Department of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Objective: Congenital heart block (CHB) in patients with neonatal lupus erythematosus (NLE) is usually irreversible. Our study aimed to investigate the clinical characteristics and prognostic follow-up results of patients with NLE presenting with CHB and to provide a reference for the clinical treatment and management of such patients.
Methods: Six patients with NLE and CHB at the Children's Hospital of Soochow University between January 1, 2011, and December 31, 2023, were retrospectively analyzed.
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