Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/ehjci/jead109 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
First bioarchaeological evidence of the familial practice of embalming of infant and adult relatives in Early Modern France.
Sci Rep
November 2024
UMR 5199 PACEA, CNRS, Université de Bordeaux, Pessac, 33615, France.
While medieval and modern embalming practices in Western Europe are attested to historically and bioarcheologically, especially for famous historical figures, there are few recorded occurrences of this type of corpse preparation for a large number of archaeological individuals from the same lineage. Moreover, evidence of such practices mainly concerns adult individuals, whereas traces of child embalming are extremely rare. In 2017, the discovery of a crypt in the chapel of the Château des Milandes (Castelnaud-la-Chapelle, Dordogne, France) revealed a collective burial of the scattered remains of seven adults and five children of the aristocratic Caumont family, who died in the 16th and 17th centuries and whose skeletons all show marks of embalming practices.
View Article and Find Full Text PDFMorphological, electrophysiological, and molecular alterations in foetal noncompacted cardiomyopathy induced by disruption of ROCK signalling.
Front Cell Dev Biol
October 2024
Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Left ventricular noncompaction cardiomyopathy is associated with heart failure, arrhythmia, and sudden cardiac death. The developmental mechanism underpinning noncompaction in the adult heart is still not fully understood, with lack of trabeculae compaction, hypertrabeculation, and loss of proliferation cited as possible causes. To study this, we utilised a mouse model of aberrant Rho kinase (ROCK) signalling in cardiomyocytes, which led to a noncompaction phenotype during embryogenesis, and monitored how this progressed after birth and into adulthood.
View Article and Find Full Text PDFCardiovascular magnetic resonance insights into anomalies of the mitral valve apparatus in Fabry cardiomyopathy and hypertrophic cardiomyopathy.
Front Cardiovasc Med
September 2024
Multimodality Cardiac Imaging Section, IRCCS Policlinico San Donato, Milan, Italy.
Article Synopsis
- Fabry Disease cardiomyopathy (FDc) and sarcomeric hypertrophic cardiomyopathy (HCM) show similar hypertrophic heart features, particularly anomalies of the mitral valve apparatus (AMVA), which were assessed in this study for better diagnosis and understanding of disease progression.
- The study involved 80 Fabry patients and 40 HCM patients, utilizing cardiovascular magnetic resonance (CMR) imaging to measure various AMVA and compare groups with similar levels of left ventricular hypertrophy.
- Results indicated that Fabry patients exhibited greater hypertrophy of papillary muscles compared to HCM patients, alongside significant anomalies like apical displacement, supporting the idea that AMVA may serve as early indicators in Fabry disease. *
Glucose-Stimulated Mucus Secretion by Goblet Cells Mitigates Intestinal Barrier Dysfunction in a Rat Model of Mesenteric Ischemia/Reperfusion Injury.
Curr Dev Nutr
September 2024
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan.
Background: Superior mesenteric ischemia/reperfusion (I/R) causes barrier dysfunction and facilitates bacterial translocation (BT) in the small intestine, which can even lead to systemic sepsis. Our previous research showed that luminal administration of glucose and its anaerobic glycolytic metabolites exerted cytoprotective effects on epithelial cells and ameliorated I/R-induced BT in the liver and spleen. Notably, the reduction of BT occurs over the whole intestinal tract, not only restricted in the ligated glucose-containing loop.
View Article and Find Full Text PDFMicrobiota-induced S100A11-RAGE axis underlies immune evasion in right-sided colon adenomas and is a therapeutic target to boost anti-PD1 efficacy.
Gut
January 2025
Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China
Background: Tumourigenesis in right-sided and left-sided colons demonstrated distinct features.
Objective: We aimed to characterise the differences between the left-sided and right-sided adenomas (ADs) representing the early stage of colonic tumourigenesis.
Design: Single-cell and spatial transcriptomic datasets were analysed to reveal alterations between right-sided and left-sided colon ADs.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!