Digital twins (DTs) are an emerging phenomenon in the public and private sectors as a new tool to monitor and understand systems and processes. DTs have the potential to change the status quo in ecology as part of its digital transformation. However, it is important to avoid misguided developments by managing expectations about DTs. We stress that DTs are not just big models of everything, containing big data and machine learning. Rather, the strength of DTs is in combining data, models, and domain knowledge, and their continuous alignment with the real world. We suggest that researchers and stakeholders exercise caution in DT development, keeping in mind that many of the strengths and challenges of computational modelling in ecology also apply to DTs.
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http://dx.doi.org/10.1016/j.tree.2023.04.010 | DOI Listing |
Water Res
December 2024
School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Marine Pollution, City University of Hong Kong, Hong Kong SAR, China. Electronic address:
Airflow models are powerful tools for ventilation design to achieve odour and corrosion mitigation in sewer networks. Currently, there lacks a model able to efficiently predict in-sewer dynamic airflows, as all available dynamic models with an acceptable accuracy are computationally demanding. In this study, a swift dynamic airflow model based on an ordinary differential equation (ODE) is derived by simplifying the one-dimensional Navier Stokes Equations (NSE), supported by the observation that the NSE solutions always display negligible spatial variations in air velocity when applied to a sewer conduit.
View Article and Find Full Text PDFPLoS One
January 2025
ESQlabs Gmbh, Saterland, Germany.
Digital twins, driven by data and mathematical modelling, have emerged as powerful tools for simulating complex biological systems. In this work, we focus on modelling the clearance on a liver-on-chip as a digital twin that closely mimics the clearance functionality of the human liver. Our approach involves the creation of a compartmental physiological model of the liver using ordinary differential equations (ODEs) to estimate pharmacokinetic (PK) parameters related to on-chip liver clearance.
View Article and Find Full Text PDFBackground: Amyloid, Tau and neurodegeneration (ATN), the hallmark pathologies of Alzheimer's Disease (AD) translating to measurable biomarkers are important for disease modifying therapeutics.
Method: AD Digital-Twins were built using AITIA's patented A.I.
Alzheimers Dement
December 2024
Department of Biomedical Engineering, McGill University, Montreal, QC, Canada.
Background: Randomized placebo-controlled trials (RCTs) are the gold standard to evaluate efficacy of new drug treatments for Alzheimer's disease. For example, the United States FDA approved the brain amyloid-targeting drug lecanemab following CLARITY AD, Biogen and Eisai's Phase 3 RCT. However, recruiting enough participants for a high-powered and demographically representative trial is difficult and expensive.
View Article and Find Full Text PDFBackground: In Alzheimer's Disease (AD) trials, clinical scales are used to assess treatment effect in patients. Minimizing statistical uncertainty of trial outcomes is an important consideration to increase statistical power. Machine learning models can leverage baseline data to create AI-generated digital twins - individualized predictions (or prognostic scores) of how each patient's clinical outcomes may change during a trial assuming they received placebo.
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