AI Article Synopsis
- The study investigates how the PNPLA3 rs738409 genetic variant affects kidney function decline in post-menopausal women with type 2 diabetes over five years.
- It found that women with the CG or GG genotypes of this variant experienced a significantly faster decline in estimated glomerular filtration rate (eGFR) compared to those with the CC genotype.
- The results suggest that the risk allele (G) is linked to eGFR decline, regardless of other factors like age, blood sugar levels, and medication use.
Article Abstract
Background And Aims: Little is known about the relationship between patatin-like phospholipase domain-containing protein-3 (PNPLA3) rs738409 variant and decline in estimated glomerular filtration rate (eGFR) over time in individuals with type 2 diabetes (T2DM).
Methods And Results: We enrolled an outpatient sample of 46 post-menopausal women with T2DM and preserved kidney function at baseline (in 2017), who were followed through 2022. eGFR and albuminuria were measured annually. Genotyping of PNPLA3 rs738409 was performed by TaqMan-based RT-PCR system. Overall, 25 (54.3%) patients had PNPLA3 rs738409 CC (homozygous wild-type) genotype and 21 had CG or GG genotypes. During the 5-year follow-up, the presence of rs738409 CG/GG genotypes was associated with faster eGFR decline (coefficient: -6.55; 95% CI -11.0 to -2.08; p = 0.004 by random-effects panel data analysis). This association remained significant even after adjustment for 5-year changes in age, hemoglobin A1c, hypertension status, albuminuria and use of sodium-glucose co-transporter-2 inhibitors or glucagon-like peptide-1 receptor agonists.
Conclusions: This pilot study suggests that in post-menopausal T2DM women with preserved kidney function at baseline, the risk allele (G) of PNPLA3 rs738409 is associated with a faster eGFR decline during a 5-year follow-up, independent of annual changes in common renal risk factors and use of certain glucose-lowering medications.
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| http://dx.doi.org/10.1016/j.numecd.2023.03.004 | DOI Listing |
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