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Evaluation of potential inhibitory effects on acetylcholinesterase, pancreatic lipase, and cancer cell lines using raw leaves extracts of three fabaceae species. | LitMetric
The present study examined the biological potential and phytochemicals of , and methanolic leaf extracts. anti-acetylcholinesterase and anti-lipase assays were performed using different concentrations of plant extracts, and the IC values were determined. The cytotoxic potential of the selected plant extracts was assessed against HeLa, PC3, and 3T3 cell lines using an MTT assay. leaf extract displayed the highest inhibition percentage (114.60% ± 19.95 at 1000 μg/mL) for the anti-acetylcholinesterase activity with a prominent IC value of 75.9 μg/mL. The anti-lipase potential was highest with the leaf extract (355.5 μg/mL IC), followed by the extract (862.7 μg/mL IC). Among the cell lines tested, the cytotoxic potential of the extract (91.1 ppm IC) against the PC3 cell line was promising. High-performance liquid chromatography revealed gallic acid, chlorogenic acid, caffeic acid, vanillic acid, rutin trihydrate, and quercetin dihydrate in varying concentrations in all plant species. The concentration of chlorogenic acid (69.09 ppm) was highest in , and the caffeic acid concentration (45.20 ppm) was higher in This paper reports the presence of bioactive therapeutic compounds in selected species of the Fabaceae family that could be micro-propagated, isolated, and utilized in pharmaceutical industries.
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