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Proton Pump Inhibitor Use and Worsening Kidney Function: A Retrospective Cohort Study Including 122,606 Acid-Suppressing Users.
J Gen Intern Med
December 2024
Centro Español de Investigación Farmacoepidemiológica (CEIFE), Spanish Centre for Pharmacoepidemiologic Research, Madrid, Spain.
Background: The impact of proton pump inhibitors (PPIs) use on worsening renal function is controversial and lacks a solid pathophysiological explanation.
Objective: To assess the risk of worsening renal function and acute kidney injury (AKI) in PPI initiators as compared with H2-blockers initiators.
Design: Retrospective cohort study using longitudinal records from BIGAN, a population-based health database of Aragón (Spain).
Integrating network pharmacology and experimental verification to study the mechanism of total flavonoids against stress-induced gastric mucosal damage.
Heliyon
October 2024
Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, International Joint Research Center of Human-machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province, Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, China.
Context: L. () has outstanding clinical efficacy in treating both acute and chronic gastroenteritis. However, the definite mechanism remains unclear.
View Article and Find Full Text PDFAmeliorative Effects of HT074-Inula and Paeonia Extract Mixture on Acute Reflux Esophagitis in Rats via Antioxidative Activity.
Antioxidants (Basel)
July 2024
Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
HT074, a multiherbal mixture containing extracts from flowers and roots, is used in Korean medicine for gastric disorders. This study investigated the protective mechanisms of HT074 against acute reflux esophagitis (RE) in rats. Nitric oxide (NO) production and mRNA expression of antioxidant-related genes (, , , , and ) were evaluated in LPS-induced RAW 264.
View Article and Find Full Text PDFProbiotic bacteria protect against indomethacin-induced gastric ulcers through modulation of oxidative stress, inflammation, and apoptosis.
Mol Biol Rep
May 2024
Department of Physiology, Veterinary Faculty, Kafkas University, Kars, Turkey.
Background: Indomethacin is an anti-inflammatory drug that causes ulcers on the gastric mucosa due to its use. Probiotic bacteria are live microorganisms, and it has been stated by various studies that these bacteria have antioxidant and anti-inflammatory effects. In this study, we investigated the possible protective effect of various types of probiotic bacteria (Lactobacillus rhamnosus, Lactobacillus fermentum, and Lactobacillus brevis) against acute gastric mucosal damage caused by indomethacin.
View Article and Find Full Text PDFTreatment of acute urticaria: A systematic review.
J Eur Acad Dermatol Venereol
November 2024
SKIN Research Group, Vrije Univeristeit Brussel (VUB), Brussels, Belgium.
There are only a few clinical trials which address the treatment of acute urticaria (AU). Especially, the added value of systemic corticosteroids to antihistamines is unclear in treatment of severe AU. To review the existing evidence-based approaches for AU treatment.
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