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Background: Bulimia nervosa (BN) is a serious mental illness with impulsivity as a cardinal symptom. Impulsivity contributes to various other, often comorbid, mental disorders, such as attention deficit/hyperactivity disorder (ADHD) and borderline personality disorder (BPD). The aim of this study was to explore comorbidities of BN with ADHD and BPD as well as the contribution of impulsivity as an underlying trait linking these disorders.
View Article and Find Full Text PDFReal-Time Auto Controlling of Viable Cell Density in Perfusion Cultivation Aided by In-Line Dielectric Spectroscopy With Segmented Adaptive PLS Model.
Biotechnol Bioeng
January 2025
Bioprocess Research and Development (BRD), WuXi Biologics, Shanghai, China.
Serving as a dedicated process analytical technology (PAT) tool for biomass monitoring and control, the capacitance probe, or dielectric spectroscopy, is showing great potential in robust pharmaceutical manufacturing, especially with the growing interest in integrated continuous bioprocessing. Despite its potential, challenges still exist in terms of its accuracy and applicability, particularly when it is used to monitor cells during stationary and decline phases. In this study, data pre-processing methods were first evaluated through cross-validation, where the first-order derivative emerged as the most effective method to diminish variability in prediction accuracy across different training datasets.
View Article and Find Full Text PDFIs measurement uncertainty from sampling related to analyte concentration?
Anal Methods
November 2017
LGC Limited, Queens Road, Teddington, Middlesex TW11 0LY, UK.
The contribution of sampling to the combined uncertainty of measurement is assessed using a combination of literature review and experimental determination of sampling variability in a range of foodstuffs in order to determine whether there is a consistent relationship between analyte level and proportion of variation attributable to sampling. Experimental determinations used the duplicate method, an economical method of assessing the relative contributions of sampling and analytical variability to the overall variance of results. The experimental work covered sampling of retail foodstuffs.
View Article and Find Full Text PDFMetabolic pathways of eicosanoids-derivatives of arachidonic acid and their significance in skin.
Cell Mol Biol Lett
January 2025
Department of Analytical Chemistry, Medical University of Bialystok, Kilinskiego 1, 15-069, Bialystok, Poland.
The skin is a barrier that protects the human body against environmental factors (physical, including solar radiation, chemicals, and pathogens). The integrity and, consequently, the effective metabolic activity of skin cells is ensured by the cell membrane, the important structural and metabolic elements of which are phospholipids. Phospholipids are subject to continuous transformation, including enzymatic hydrolysis (with the participation of phospholipases A, C, and D) to free polyunsaturated fatty acids (PUFAs), which under the influence of cyclooxygenases (COX1/2), lipoxygenases (LOXs), and cytochrome P450 (CYPs P450) are metabolized to various classes of oxylipins, depending on the type of PUFA being metabolized and the enzyme acting.
View Article and Find Full Text PDFEnergy feature extraction and visualization of voltage sags using wavelet packet analysis for enhanced power quality monitoring.
Sci Rep
January 2025
Department of Theoretical Electrical Engineering and Diagnostics of Electrical Equipment, Institute of Electrodynamics, National Academy of Sciences of Ukraine, Beresteyskiy, 56, Kyiv-57, Kyiv, 03680, Ukraine.
Power quality (PQ) disturbances, such as voltage sags, are significant issues that can lead to damage in electrical equipment and system downtime. Detecting and classifying these disturbances accurately is essential for maintaining reliable power systems. This paper introduces a novel approach to voltage sag analysis by employing wavelet packet analysis combined with energy-based feature extraction to enhance PQ monitoring.
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