AI Article Synopsis
- A study focused on children with cerebral palsy and epilepsy aimed to determine how often they experience paroxysmal nonepileptic events and identify any related factors.
- Analyzing data from 256 children, researchers found that 26% experienced paroxysmal nonepileptic events, with many of these children also having epileptic events.
- Parents often misidentified nonepileptic events as epileptic, emphasizing the importance of better education and counseling for families about seizure types and their characteristics.
Article Abstract
To determine the frequency of paroxysmal nonepileptic events in children with cerebral palsy due to brain injury who have epilepsy and to describe the factors associated with paroxysmal nonepileptic events. Retrospective, population-based study of children from the Victorian CP Register born 1999-2006. Neuroimaging, medical records, electroencephalograms (EEG), and EEG requests were analyzed. Of the included 256 children, 87 had epilepsy. EEGs (with video correlation) were available for 82 of 87. Eighteen (18/82, 22%) had epileptic events captured on EEG. Twenty-one (21/82, 26%) had paroxysmal nonepileptic events captured on EEG. The majority (13/18, 77%) of children with epileptic events also had paroxysmal nonepileptic events captured. Ten parents and carers continued to report events as epileptic despite there being no ictal EEG correlate for specific events on multiple EEGs. There were no clear associations to identify which children would have ongoing paroxysmal nonepileptic events reported. Paroxysmal nonepileptic events were captured on EEG in one-fourth of children from this cerebral palsy cohort with epilepsy and available EEG. Half the parents and carers reported previously identified paroxysmal nonepileptic events as epileptic on subsequent EEGs, highlighting the need for clearer counseling so that parents better understand seizure semiology in children with EEG-proven paroxysmal nonepileptic events.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/08830738231176055 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
-Associated Paroxysmal Dystonia.
Tremor Other Hyperkinet Mov (N Y)
December 2024
Veracity Neuroscience LLC, Memphis, Tennessee, USA.
Background: mutations are associated with a diverse set of distinct neurological syndromes and intermediate phenotypes that may include extra-neural features. Overall, genotype-phenotype correlations are weak. There are no consensus treatments.
View Article and Find Full Text PDFKCNMA1-Related Episodes of Behavioral Arrest and Loss of Postural Reflexes: A Critical Reappraisal.
Mov Disord Clin Pract
December 2024
Service de Neuropédiatrie, CHU Montpellier, Montpellier, France.
Article Synopsis
- - KCNMA1-linked channelopathy leads to neurodevelopmental disorders, epilepsy, and non-epileptic episodes characterized by specific facial, behavioral, and physical symptoms.
- - A review of 14 videos highlighted typical episode features: facial changes, behavioral arrest, loss of postural control, and quick recovery without drowsiness, with episodes often triggered by emotions.
- - Distinguishing KCNMA1-related attacks from other conditions like paroxysmal dyskinesia and cataplexy will improve accurate diagnosis and targeted treatment for affected individuals.
Case Report: Ocular paroxysmal non-epileptic events as the presenting sign of celiac disease in children: a case series.
Front Pediatr
October 2024
Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Article Synopsis
- Neurologic symptoms can sometimes signal celiac disease (CD), and two children with ocular paroxysmal non-epileptic events (PNEEs) were diagnosed with CD.
- A review of 12 patients showed that 25% were also diagnosed with CD after presenting with similar symptoms.
- Screening for CD in patients displaying PNEEs may be beneficial in order to avoid unnecessary testing and to quickly implement a gluten-free diet, potentially improving their condition.
Neonatal hyperekplexia: a non-epileptic paroxysmal movement disorder with a novel homozygous mutation in the GLRB gene, a seizure mimic.
BMJ Case Rep
October 2024
Paediatrics, King George's Medical University, Lucknow, Uttar Pradesh, India.
A male baby born out of consanguineous marriage (third degree) to a primigravida mother presented to our hospital on day 21 of life as his third hospitalisation with jerky movements, respiratory distress and refusal to feed. The baby had blood culture-positive sepsis, which was treated adequately. He was given antiseizure therapy for jerky movements, but there was no response to multiple antiseizure therapy, and then pyridoxine was added.
View Article and Find Full Text PDFInsight of autonomic dysfunction in CLN3 disease: a study on episodes resembling paroxysmal sympathetic hyperactivity (PSH).
Orphanet J Rare Dis
October 2024
Department of Children and Adolescence, Centre for Rare Diseases, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus, Denmark.
Article Synopsis
- The study investigates autonomic activity in adolescents with Juvenile Ceroid Lipofuscinosis (CLN3-disease) experiencing recurrent non-epileptic episodes resembling paroxysmal sympathetic hyperactivity (PSH).
- Researchers monitored heart rate variability (HRV) over a week and focused on HRV parameters before, during, and after PSH-like episodes in seven Danish patients aged 15 and older.
- Results indicated a significant drop in parasympathetic activity just before PSH-like episodes and maintained low levels during and shortly after the episodes, while sympathetic activity remained unchanged, suggesting sympathetic overactivity during these events.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!