AI Article Synopsis
- A study was conducted to evaluate sleep problems in children diagnosed with NMDA receptor encephalitis, revealing that 95% experienced sleep dysfunction at onset.
- At the one-year mark, 34% continued to report sleep issues, indicating a significant persistence of sleep problems over time.
- Notably, while sleep issues at onset and the use of propofol did not relate to poor outcomes, poor sleep at one year did correlate with unfavorable modified Rankin Scores, suggesting the need for further research on sleep and long-term outcomes in these patients.
Article Abstract
Rates of sleep problems in children with anti-methyl-d-aspartate (NMDA) receptor encephalitis are unknown. We used a retrospective observational cohort database of children with a diagnosis of NMDA receptor encephalitis at a single freestanding institution. One-year outcomes were assessed with the pediatric modified Rankin Score (mRS), with 0 to 2 as good and 3 or greater as poor outcome. Ninety-five percent (39/41) of children with NMDA receptor encephalitis had sleep dysfunction at onset; 34% (11/32) reported sleep problems at 1 year. Sleep problems at onset and propofol use were not associated with poor outcomes at 1 year. Poor sleep at 1 year correlated with mRS scores (range 2-5) at 1 year. High rates of sleep dysfunction occur in children with NMDA receptor encephalitis. Persistent sleep problems at 1 year may correlate with outcomes as assessed by mRS at 1 year. Further studies comparing the relationship of poor sleep with outcomes in NMDA receptor encephalitis are needed.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10524468 | PMC |
| http://dx.doi.org/10.1177/08830738231173603 | DOI Listing |
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