Despite increased research on 'multiple hazards' and 'cascading effects', ambiguity remains concerning terminology. This paper reviews the literature to explore how these two concepts are defined in relation to critical infrastructures and their vital societal functions. Next, it investigates how the concepts are operationalised in Swedish disaster risk management. Findings indicate that regardless of a wealth of methodologies assessing multiple hazards and their cascading effects, these are rarely used by local planners, suggesting a gap between scientific approaches and practical implementation. Research mainly captures multiple hazards and cascading effects through technical parameters related to the severity of a hazard or the direct physical impacts on infrastructure. Less focus has been placed on the wider or knock-on effects across sectors and how these translate into societal risk. Future research should move beyond traditional understandings of social vulnerabilities as only pre-existing, to analyse how cascading effects on infrastructure and services can put new social groups at risk.
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http://dx.doi.org/10.1111/disa.12591 | DOI Listing |
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December 2024
State Key Laboratory of Oral Diseases, School of Chemical Engineering, National Center for Stomatology & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, 610041, China.
Intractable implant-associated infections (IAIs) are the primary cause of prosthetic implant failure, particularly in the context of diabetes mellitus. There is an urgent need to design and construct versatile engineered implants integrated with cascade amplification therapeutic modality to significantly improve the treatment of diabetic IAIs. To address this issue, a multi-functional MXene/AgPO@glucose oxidase bio-heterojunction enzyme (M/A@GOx bio-HJzyme) coating is developed, which is decorated with an inert sulfonated polyetheretherketone implant (SP-M/A@G) via hydrothermal treatment and layered deposition.
View Article and Find Full Text PDFJ Steroid Biochem Mol Biol
December 2024
Department of Rehabilitation Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. Electronic address:
Segetalin B (SB) has shown promise in mitigating osteoporosis in ovariectomized (OVX) mice, though its underlying mechanisms remain unclear. This study investigates how SB promotes bone formation through Phospholipase D1 (PLD1) activation in OVX models. In vitro, bone marrow-derived mesenchymal stem cells (BMSCs) from OVX mice were cultured for osteogenic differentiation.
View Article and Find Full Text PDFWorld J Gastroenterol
December 2024
Department of Gastroenterology, University of Balamand, Beirut 3187, Beyrouth, Lebanon.
(. ) is widely used in traditional Chinese medicine due to its anti-tumor effects. .
View Article and Find Full Text PDFTher Adv Hematol
December 2024
Division of Hematology and Oncology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9255, USA.
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder which is caused by mutations in phosphatidylinositol glycan class A leading to hemolysis of red blood cells via complement inhibition. The first treatment for PNH, eculizumab, was FDA approved in 2007. Since then, many new treatment options for PNH have arisen.
View Article and Find Full Text PDFNeurosci Lett
December 2024
School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA, USA; Department of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, USA; Veterans Affairs Medical Center, Salem, VA, USA. Electronic address:
Regulation of glutamate through glutamate-glutamine cycling is critical for mediating nervous system plasticity. Blast-induced traumatic brain injury (bTBI) has been linked to glutamate-dependent excitotoxicity, which may be potentiating chronic disorders such as post-traumatic epilepsy. The purpose of this study was to measure changes in the expression of astrocytic and neuronal proteins responsible for glutamatergic regulation at 4-, 12-, and 24 h in the cortex and hippocampus following single blast exposure in a rat model for bTBI.
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