AI Article Synopsis
- Catalytic enantioselective methods are scarce for varied substrates, prompting a new strategy for oxidative desymmetrization of diols.
- This method involved optimizing a peptide-based catalyst by testing multiple screening substrates instead of just one.
- The resulting catalyst showed impressive enantioselectivity for lactones and could operate with up to ~100,000 turnovers.
Article Abstract
Catalytic enantioselective methods that are generally applicable to a broad range of substrates are rare. We report a strategy for the oxidative desymmetrization of -diols predicated on a nontraditional catalyst optimization protocol by using a panel of screening substrates rather than a singular model substrate. Critical to this approach was rational modulation of a peptide sequence in the catalyst incorporating a distinct aminoxyl-based active residue. A general catalyst emerged, providing high selectivity in the delivery of enantioenriched lactones across a broad range of diols, while also achieving up to ~100,000 turnovers.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277815 | PMC |
| http://dx.doi.org/10.1126/science.adf6177 | DOI Listing |
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