AI Article Synopsis
- A new strategy has been created for synthesizing phosphonylated spirocyclic indolines using CpFe-catalyzed electrochemical dearomatization, overcoming challenges faced with traditional chemical oxidants.
- The process resulted in moderate to good yields of phosphonylated 3,3-spiroindolines, achieving excellent diastereoselectivity.
- The method is notable for its scalability and shows potential antitumor activity for the synthesized products.
Article Abstract
A general and robust strategy for the synthesis of phosphonylated spirocyclic indolines has been developed through CpFe-catalyzed electrochemical dearomaztizaion of indoles, which has been proven challenging to achieve via chemical oxidants. A range of phosphonylated 3,3-spiroindolines were obtained in moderate to good yields with excellent diastereoselectivities. The synthetic application was further illustrated by its easy scalability and the antitumor activity of the product.
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| http://dx.doi.org/10.1021/acs.orglett.3c01368 | DOI Listing |
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